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• W2312865893 abstract "Objectives: The efficacy and safety of once daily ritonavir-boosted atazanavir (ATV/r) plus tenofovir (TDF) and emtricitabine (FTC) or lamivudine (3TC) was evaluated in the management of treatment experienced HIV-infected patients in routine clinical practice.Research design and methods: A retrospective analysis was performed in HIV infected patients residing at two active, urban clinical practices receiving at least one month of tenofovir, emtricitabine or lamviudine plus ritonavir boosted atazanavir following a change from another antiretroviral regimen to simplify or reduce toxicity. Parameters evaluated included the proportion of patients with HIV RNA <400 copies/mL; change in CD4 count from baseline (start of both TDF and ATV/r), adverse effects, and laboratory changes over time in estimated glomerular filtration rate (calculated creatinine clearance and MDRD) and lipids.Main outcome measures: One hundred sixty five patients, the majority being Caucasian and male, were studied. Twenty nine (18%) discontinued therapy, including 4 for adverse events and 5 for virologic failure. At baseline, 71% of patients had HIV RNA values <400 copies/mL. At 12 months, 81/90 (90%) patients remaining on therapy had HIV RNA <400 copies/mL, including 17/25 (68%) of those with baseline HIV RNA ≥400 copies/m; 88% (35/40) achieved HIV RNA <75 c/mL. Median increase in CD4 count at 12 months was 26 cells/uL. Grade 4 hyperbilirubinemia occurred in 12% of patients. Estimated glomerular filtration rates did not change significantly by either the Cockcroft-Gault or MDRD method. At 12 months, median declines from baseline in total cholesterol, LDLcholesterol, HDL-cholesterol, and triglycerides were -14, -18, -1, and -12 mg/dL, respectively.Conclusions: In routine clinical practice, a once-daily regimen containing ATV/r plus TDF/FTC or 3TC controlled HIV in most patients without renal toxicity and improved the lipid profile." @default.
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• W2312865893 date "2012-01-01" @default.
• W2312865893 modified "2023-09-23" @default.
• W2312865893 title "Safety and Effectiveness of Tenofovir/Emtricitabine or Lamivudine Plus Ritonavir Boosted Atazanavir in Treatment Experienced HIV Infected Adults at Two Urban Private Medical Practices" @default.
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• W2312865893 doi "https://doi.org/10.4172/jaa.1000038" @default.
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