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• W2312917916 abstract "Event Abstract Back to Event Dynamic changes of T-Regulatory/Dendritic Cell Subsets and IL-17/TGF-β Gene Expression in Stable Kidney Transplanted Patients Hassan Nikoueinejad1, 2*, Aliakbar Amirzargar1, Pedram Ahmadpoor3, Mohsen Nafar3 and Behzad Einollahi4 1 Tehran University of Medical Sciences, Iran 2 Kashan University of Medical Sciences, Iran 3 Shahid Beheshti University of Medical Sciences, Iran 4 Baqiyatallah University of Medical Sciences, Iran Introduction: Survival upon kidney transplantation depends mainly on its function during the first year post-transplantation (1-2). Clearly, serial biopsy remains the best way to detect immune status of the graft, but it has not favored both the patient and the physician due to being aggressive and having a 0.5% rate of side-effects (3). It is also associated with sampling errors and interpretation biases (4). It seems that biomarkers can help us better evaluate the immune status of transplant recipients (4-6). We aimed to identify the immune status of the stable renal allografts from the point of some cellular and molecular changes that may occur after transplantation. Patients and Methods: This prospective study considered 57 consecutive patients who not rejected during 1 year after transplantation. Flow-cytometric frequencies of circulatory CD4+CD25+FoxP3+ and CD8+CD28- T regulatory cells (Treg), myeloid dendritic cells type 1 (mDC1) and 2 (mDC2), plasmacytoid dendritic cells (pDC), and real-time PCR-evaluated gene expression level of IL-17 and TGF-β of peripheral blood mononuclear cells were measured before transplantation, 2 weeks, 1, 3, 6, and 12 months after transplantation. Results: The mean number of Tregs and pDCs decreased 2 weeks after transplantation (P<0.001) and then increased as they reached their values before transplantation within one month in the case of pDCs (P=0.16) and 6 months in the case of CD4+CD25+FoxP3+ Tregs (P=0.338). The mean number of mDC1s and the gene expression of TGF-β increased 2 weeks after transplantation (P=0.002) and then decreased till the end of follow up as they reached their values before transplantation within 6 months in the case of mDC1s (P=0.714) and 3 months in the case of TGF-β gene expression (P=0.18). There were no significant changes in the mean number of mDC2s till the 6th month (P=0.041). Despite the expression of internal control of IL-17, there was not any expression of IL-17. Conclusion: The circulatory changes in the frequency of Tregs and pDCs are opposite to mDCs after kidney transplantation. Also the gene expression level of TGF-β is decreasing after 2 weeks post-transplantation. We describe these changes in a group of patients with stable graft; however our study does not render any idea in patients with unstable/rejecting grafts. Comparison of such frequencies with those in unstable/rejecting patients (taken from further studies) may differentially identify non-rejecting patients who likely will not develop acute rejection after transplantation. References 1-Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein, D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000; 342: 605. 2-Hariharan S, McBride MA, Cherikh WS, Tolleris CB, Bresnahan B, Johnson CP. Post-transplant renal function in the first year predicts long-term kidney transplant survival. Kidney Int 2002; 62: 311. 3-Furness PN, Philpott CM, Chorbadjian MT, et al. Protocol biopsy of the non-rejected renal transplant: a multicenter study of methods and complication rates. Transplantation 2003; 76: 969. 4-Hernandez-Fuentes MP. Lechler RI. A ‘biomarker signature’ for tolerance in transplantation. Nat Rev Nephrol 2010; 6: 606. 5-Pervinder S, Esperanza P, Birgit S, et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010; 120: 1848. 6-Sánchez-Fueyo A, Strom TB. Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs. Gastroenterology 2011; 140: 51. Keywords: Renal transplantation, regulatory T cells, Dendritic Cells, TGF-β, IL-17 Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: Nikoueinejad H, Amirzargar A, Ahmadpoor P, Nafar M and Einollahi B (2013). Dynamic changes of T-Regulatory/Dendritic Cell Subsets and IL-17/TGF-β Gene Expression in Stable Kidney Transplanted Patients. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00462 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Hassan Nikoueinejad, Tehran University of Medical Sciences, Tehran, Iran, hnikuinejad@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract Supplemental Data The Authors in Frontiers Hassan Nikoueinejad Aliakbar Amirzargar Pedram Ahmadpoor Mohsen Nafar Behzad Einollahi Google Hassan Nikoueinejad Aliakbar Amirzargar Pedram Ahmadpoor Mohsen Nafar Behzad Einollahi Google Scholar Hassan Nikoueinejad Aliakbar Amirzargar Pedram Ahmadpoor Mohsen Nafar Behzad Einollahi PubMed Hassan Nikoueinejad Aliakbar Amirzargar Pedram Ahmadpoor Mohsen Nafar Behzad Einollahi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2312917916 title "Dynamic changes of T-Regulatory/Dendritic Cell Subsets and IL-17/TGF-� Gene Expression in Stable Kidney Transplanted Patients" @default.
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