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- W2312919592 abstract "The present study was conducted to examine whether dopaminergic activity in the striatum is involved in the mechanism of benzodiazepine-induced eating. The changes in dopaminergic activity were measured in Wistar rats weighing 350 to 400g using microdialysis method. Relative concentrations of dopamine in the dialysate collected from the striatum decreased after the injection of diazepam (160μg), a benzodiazepine agonist, into the lateral ventricle of the rats. The concentrations reached a minimum level between 40 and 60min, and returned to a normal level within 120min after the administration. The levels of dopamine in control rats maintained almost constant levels. Food intake was significantly (p<0.01) increased following an intracerebroventricular injection of diazepam (160μg). Bilateral injections of dopamine (20μg)into the striatum did not change food intake. However, diazepam-induced eating was significantly (p<0.01) suppressed by the administration of dopamine. These results suggested that benzodiazepines may decrease striatal dopaminergic activity, and stimulate feeding behavior." @default.
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- W2312919592 title "Involvement of Dopamine in the Mechanism of Benzodiazepine-Induced Eating" @default.
- W2312919592 doi "https://doi.org/10.2508/chikusan.67.281" @default.
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