FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2312920910> ?p ?o ?g. }

• W2312920910 abstract "Introduction Pseudomonas aeruginosa (PA) is one of the most important pathogens in cystic fibrosis (CF). Although there is a wealth of data about the prevalence of chronic PA infection, there is a paucity of evidence about the incidence of new PA infection. Methods The SPACE (Sensitivity and specificity of PA detection using the hydrogen Cyanide concentration of Exhaled breath) study investigated if exhaled breath hydrogen cyanide is an early marker of PA infection in children with CF. Breath samples, clinical data and microbiology samples were collected at each out-patient appointment from a large cohort of children with CF who had not isolated PA for >12 months. This abstract reports the PA acquisition data. Results 233 children were followed for a median of 2.0 (1.7–2.3) years. The median (IQR) age was 8.0 (5.0–12.2) years. 71 children isolated PA during the study period. The incidence rate (95% CI) of new PA infections was 0.15 (0.10–0.22) cases per patient year for those that had never previously isolated PA and 0.19 (0.13–0.27) cases per patient year for those that had been free from PA for >12 months. This rate varied between 0.08 (0.04–0.18) and 0.28 (0.14–0.49) cases per patient year at the 8 recruiting centres. 42% of children were asymptomatic at the time of PA acquisition. The median (IQR) number of antibiotic courses per patient year varied between the centres: 0.6 (0.2–1.3) to 3.6 (3.1–4.2) for oral and 0.0 (0–0) to 0.4 (0–1.2) for intravenous. Conclusions This is the first prospective study to report the incidence of new PA infection in a large cohort of children with CF, considered to be free of PA airway infection. Incidence rate was higher in children who had isolated PA previously. The variation between centres is not easily explained and needs further investigation. Acknowledgments We would like to thank the Principal Investigators, research nurses and co-ordinators at each of the recruiting centres as well as the children and their families." @default.
• W2312920910 created "2016-06-24" @default.
• W2312920910 creator A5000604269 @default.
• W2312920910 creator A5002268196 @default.
• W2312920910 creator A5018353192 @default.
• W2312920910 creator A5020354395 @default.
• W2312920910 creator A5036454891 @default.
• W2312920910 creator A5055126316 @default.
• W2312920910 creator A5064549012 @default.
• W2312920910 creator A5072288229 @default.
• W2312920910 creator A5089101358 @default.
• W2312920910 date "2014-11-10" @default.
• W2312920910 modified "2023-09-28" @default.
• W2312920910 title "P197 The Incidence Of New Pseudomonas Aeruginosa Infection In Children With Cystic Fibrosis" @default.
• W2312920910 doi "https://doi.org/10.1136/thoraxjnl-2014-206260.326" @default.
• W2312920910 hasPublicationYear "2014" @default.
• W2312920910 type Work @default.
• W2312920910 sameAs 2312920910 @default.
• W2312920910 citedByCount "0" @default.
• W2312920910 crossrefType "journal-article" @default.
• W2312920910 hasAuthorship W2312920910A5000604269 @default.
• W2312920910 hasAuthorship W2312920910A5002268196 @default.
• W2312920910 hasAuthorship W2312920910A5018353192 @default.
• W2312920910 hasAuthorship W2312920910A5020354395 @default.
• W2312920910 hasAuthorship W2312920910A5036454891 @default.
• W2312920910 hasAuthorship W2312920910A5055126316 @default.
• W2312920910 hasAuthorship W2312920910A5064549012 @default.
• W2312920910 hasAuthorship W2312920910A5072288229 @default.
• W2312920910 hasAuthorship W2312920910A5089101358 @default.
• W2312920910 hasBestOaLocation W23129209101 @default.
• W2312920910 hasConcept C120665830 @default.
• W2312920910 hasConcept C121332964 @default.
• W2312920910 hasConcept C126322002 @default.
• W2312920910 hasConcept C185592680 @default.
• W2312920910 hasConcept C187212893 @default.
• W2312920910 hasConcept C2776938444 @default.
• W2312920910 hasConcept C2777637488 @default.
• W2312920910 hasConcept C2777910003 @default.
• W2312920910 hasConcept C2781046861 @default.
• W2312920910 hasConcept C501593827 @default.
• W2312920910 hasConcept C523546767 @default.
• W2312920910 hasConcept C54355233 @default.
• W2312920910 hasConcept C55493867 @default.
• W2312920910 hasConcept C61511704 @default.
• W2312920910 hasConcept C71924100 @default.
• W2312920910 hasConcept C72563966 @default.
• W2312920910 hasConcept C86803240 @default.
• W2312920910 hasConcept C89423630 @default.
• W2312920910 hasConcept C90924648 @default.
• W2312920910 hasConceptScore W2312920910C120665830 @default.
• W2312920910 hasConceptScore W2312920910C121332964 @default.
• W2312920910 hasConceptScore W2312920910C126322002 @default.
• W2312920910 hasConceptScore W2312920910C185592680 @default.
• W2312920910 hasConceptScore W2312920910C187212893 @default.
• W2312920910 hasConceptScore W2312920910C2776938444 @default.
• W2312920910 hasConceptScore W2312920910C2777637488 @default.
• W2312920910 hasConceptScore W2312920910C2777910003 @default.
• W2312920910 hasConceptScore W2312920910C2781046861 @default.
• W2312920910 hasConceptScore W2312920910C501593827 @default.
• W2312920910 hasConceptScore W2312920910C523546767 @default.
• W2312920910 hasConceptScore W2312920910C54355233 @default.
• W2312920910 hasConceptScore W2312920910C55493867 @default.
• W2312920910 hasConceptScore W2312920910C61511704 @default.
• W2312920910 hasConceptScore W2312920910C71924100 @default.
• W2312920910 hasConceptScore W2312920910C72563966 @default.
• W2312920910 hasConceptScore W2312920910C86803240 @default.
• W2312920910 hasConceptScore W2312920910C89423630 @default.
• W2312920910 hasConceptScore W2312920910C90924648 @default.
• W2312920910 hasLocation W23129209101 @default.
• W2312920910 hasLocation W23129209102 @default.
• W2312920910 hasOpenAccess W2312920910 @default.
• W2312920910 hasPrimaryLocation W23129209101 @default.
• W2312920910 hasRelatedWork W1495572240 @default.
• W2312920910 hasRelatedWork W1988764658 @default.
• W2312920910 hasRelatedWork W2000714505 @default.
• W2312920910 hasRelatedWork W2026899867 @default.
• W2312920910 hasRelatedWork W2037079378 @default.
• W2312920910 hasRelatedWork W205442599 @default.
• W2312920910 hasRelatedWork W2067166661 @default.
• W2312920910 hasRelatedWork W2078891365 @default.
• W2312920910 hasRelatedWork W2102584847 @default.
• W2312920910 hasRelatedWork W2128124260 @default.
• W2312920910 hasRelatedWork W2145815678 @default.
• W2312920910 hasRelatedWork W2370324094 @default.
• W2312920910 hasRelatedWork W2442783982 @default.
• W2312920910 hasRelatedWork W2533504463 @default.
• W2312920910 hasRelatedWork W2788307821 @default.
• W2312920910 hasRelatedWork W2802594470 @default.
• W2312920910 hasRelatedWork W2980284950 @default.
• W2312920910 hasRelatedWork W3022887886 @default.
• W2312920910 hasRelatedWork W3095927495 @default.
• W2312920910 hasRelatedWork W3161936498 @default.
• W2312920910 isParatext "false" @default.
• W2312920910 isRetracted "false" @default.
• W2312920910 magId "2312920910" @default.
• W2312920910 workType "article" @default.