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- W2312942650 abstract "Abstract Objective: The aim of this study was to determine the incidence of occult bilateral involvement in Stage I epithelial ovarian cancer. Methods. We retrospectively reviewed the records of all patients ( n = 135) with Stage I epithelial ovarian cancer treated at the University of Pennsylvania Cancer Center between 1985 and 1996. A study group of patients ( n = 118) who underwent a bilateral salpingo-oophorectomy as part of their staging laparotomy was identified. Operative notes, pathology reports, and discharge summaries were reviewed to document stage, grade, histology, intraoperative impression, gross pathological description, and microscopic diagnosis. Clinically occult bilateral involvement was defined as pathologically documented ovarian involvement by tumor in an ovary that appeared normal to the surgeon during staging laparotomy. Results. The study group consisted of mostly Stage IA (79/118, 67%), followed by Stage IC (35/118, 30%) and Stage IB (4/118, 3%), tumors. In 9/118 (7.6%) of these cases, bilateral disease was documented in the pathology report. In 3/118 (2.5%) of these cases, the bilateral involvement by tumor was clinically occult at the time of surgery. In only 1/118 (0.85%) of these cases did a clinically abnormal appearing ovary not contain tumor. Conclusion. Occult involvement by early ovarian cancer is uncommon at the time of staging laparotomy. In appropriately counseled patients strongly desiring to preserve fertility, a unilateral salpingo-oophorectomy may be considered as part of a staging procedure for apparent Stage IA epithelial ovarian cancer if the contralateral ovary appears normal to the surgeon. Consideration should be given to a wedge biopsy with intraoperative frozen section to help exclude occult disease in the normal appearing ovary." @default.
- W2312942650 created "2016-06-24" @default.
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- W2312942650 date "1999-07-01" @default.
- W2312942650 modified "2023-09-25" @default.
- W2312942650 title "Occult Bilateral Involvement in Stage I Epithelial Ovarian Cancer" @default.
- W2312942650 doi "https://doi.org/10.1097/00006254-199907000-00017" @default.
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