Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313006838> ?p ?o ?g. }
- W2313006838 abstract "Renal clear cell carcinoma (RCC) when detected incidentally by ultrasonic imaging generally shows an advanced disease stage of being diagnosed metastatic as a result of lacking specific biomarkers at an early stage. To date, RCC is still ranked as the most common renal cancer and considered as one of the most treatment-resistant metastatic malignancies. In this study, a quantitative proteomics approach by means of gel-free shotgun proteomics methodology and stable isotope dimethyl labeling coupled with nano-liquid chromatography/ tandem mass (nanoLCMS/ MS) have been employed to identify 18 up-regulated and 48 down-regulated proteins in RCC samples. It is worth noting that binding and structural proteins in renal clear cells accounted for 43% and 33% of up-regulated proteins respectively, while catalytic enzymes occupied as high as 73% of down-regulated proteins. Collectively, instead of one universal tumorigenesis enzyme being identified, the pathogenesis of RCC may involve a variety of protein factors including ANXA2, LGALS1, VIM and TPM1 related to metastasis, angiogenesis, tumor invasion as well as tumor growth, in addition to CRYAB, GSTA1, CALB1 and HSPD1, which are linked to apoptosis function. The upshot of this study highlighted by a series of down-regulated proteins suggests that the clear-cut decrease of ATP generation components related to mitochondrial dysfunction and altered energy metabolism may be involved in RCC carcinogenesis." @default.
- W2313006838 created "2016-06-24" @default.
- W2313006838 creator A5012416468 @default.
- W2313006838 creator A5015395629 @default.
- W2313006838 creator A5016137582 @default.
- W2313006838 creator A5040718162 @default.
- W2313006838 creator A5063366408 @default.
- W2313006838 creator A5064314691 @default.
- W2313006838 date "2014-01-01" @default.
- W2313006838 modified "2023-09-27" @default.
- W2313006838 title "Quantitative Proteomics Analysis of Differentially Expressed Proteins Involved in Renal Clear Cell Carcinoma by Shotgun Approach Coupled with Stable Isotope Dimethyl Labeling" @default.
- W2313006838 cites W120300694 @default.
- W2313006838 cites W1522079693 @default.
- W2313006838 cites W181147267 @default.
- W2313006838 cites W1965694249 @default.
- W2313006838 cites W1972394235 @default.
- W2313006838 cites W1976610918 @default.
- W2313006838 cites W1978696565 @default.
- W2313006838 cites W1981593008 @default.
- W2313006838 cites W1988023818 @default.
- W2313006838 cites W1988989746 @default.
- W2313006838 cites W1993064494 @default.
- W2313006838 cites W1993094173 @default.
- W2313006838 cites W1993396683 @default.
- W2313006838 cites W1994766922 @default.
- W2313006838 cites W2022472106 @default.
- W2313006838 cites W2030184187 @default.
- W2313006838 cites W2030709723 @default.
- W2313006838 cites W2038088590 @default.
- W2313006838 cites W2041220742 @default.
- W2313006838 cites W2054608890 @default.
- W2313006838 cites W2058300100 @default.
- W2313006838 cites W2059525065 @default.
- W2313006838 cites W2063186742 @default.
- W2313006838 cites W2063321647 @default.
- W2313006838 cites W2063987069 @default.
- W2313006838 cites W2067544823 @default.
- W2313006838 cites W2068874557 @default.
- W2313006838 cites W2068922516 @default.
- W2313006838 cites W2070124473 @default.
- W2313006838 cites W2071243969 @default.
- W2313006838 cites W2093278804 @default.
- W2313006838 cites W2104814618 @default.
- W2313006838 cites W2107527733 @default.
- W2313006838 cites W2111930548 @default.
- W2313006838 cites W2112187659 @default.
- W2313006838 cites W2117067364 @default.
- W2313006838 cites W2126187817 @default.
- W2313006838 cites W2129407204 @default.
- W2313006838 cites W2132333834 @default.
- W2313006838 cites W2145195117 @default.
- W2313006838 cites W2145665319 @default.
- W2313006838 cites W2148898638 @default.
- W2313006838 cites W2150255388 @default.
- W2313006838 cites W2163021396 @default.
- W2313006838 cites W2164900244 @default.
- W2313006838 cites W2167390742 @default.
- W2313006838 cites W2168846334 @default.
- W2313006838 cites W2415119258 @default.
- W2313006838 cites W2417640442 @default.
- W2313006838 cites W394007346 @default.
- W2313006838 doi "https://doi.org/10.4172/jpb.s7-003" @default.
- W2313006838 hasPublicationYear "2014" @default.
- W2313006838 type Work @default.
- W2313006838 sameAs 2313006838 @default.
- W2313006838 citedByCount "2" @default.
- W2313006838 countsByYear W23130068382014 @default.
- W2313006838 countsByYear W23130068382015 @default.
- W2313006838 crossrefType "journal-article" @default.
- W2313006838 hasAuthorship W2313006838A5012416468 @default.
- W2313006838 hasAuthorship W2313006838A5015395629 @default.
- W2313006838 hasAuthorship W2313006838A5016137582 @default.
- W2313006838 hasAuthorship W2313006838A5040718162 @default.
- W2313006838 hasAuthorship W2313006838A5063366408 @default.
- W2313006838 hasAuthorship W2313006838A5064314691 @default.
- W2313006838 hasBestOaLocation W23130068381 @default.
- W2313006838 hasConcept C104317684 @default.
- W2313006838 hasConcept C121332964 @default.
- W2313006838 hasConcept C142724271 @default.
- W2313006838 hasConcept C1491633281 @default.
- W2313006838 hasConcept C185592680 @default.
- W2313006838 hasConcept C22117777 @default.
- W2313006838 hasConcept C2777472916 @default.
- W2313006838 hasConcept C2781434637 @default.
- W2313006838 hasConcept C46111723 @default.
- W2313006838 hasConcept C55493867 @default.
- W2313006838 hasConcept C60644358 @default.
- W2313006838 hasConcept C62520636 @default.
- W2313006838 hasConcept C68289359 @default.
- W2313006838 hasConcept C70721500 @default.
- W2313006838 hasConcept C71924100 @default.
- W2313006838 hasConcept C80311884 @default.
- W2313006838 hasConcept C86803240 @default.
- W2313006838 hasConcept C95444343 @default.
- W2313006838 hasConceptScore W2313006838C104317684 @default.
- W2313006838 hasConceptScore W2313006838C121332964 @default.
- W2313006838 hasConceptScore W2313006838C142724271 @default.
- W2313006838 hasConceptScore W2313006838C1491633281 @default.
- W2313006838 hasConceptScore W2313006838C185592680 @default.
- W2313006838 hasConceptScore W2313006838C22117777 @default.