Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313012562> ?p ?o ?g. }
- W2313012562 abstract "The heart responds to pathological overload through myocyte hypertrophy. Here we show that this response is regulated by cardiac fibroblasts via a paracrine mechanism involving plasma membrane calcium ATPase 4 (PMCA4). Pmca4 deletion in mice, both systemically and specifically in fibroblasts, reduces the hypertrophic response to pressure overload; however, knocking out Pmca4 specifically in cardiomyocytes does not produce this effect. Mechanistically, cardiac fibroblasts lacking PMCA4 produce higher levels of secreted frizzled related protein 2 (sFRP2), which inhibits the hypertrophic response in neighbouring cardiomyocytes. Furthermore, we show that treatment with the PMCA4 inhibitor aurintricarboxylic acid (ATA) inhibits and reverses cardiac hypertrophy induced by pressure overload in mice. Our results reveal that PMCA4 regulates the development of cardiac hypertrophy and provide proof of principle for a therapeutic approach to treat this condition." @default.
- W2313012562 created "2016-06-24" @default.
- W2313012562 creator A5006822602 @default.
- W2313012562 creator A5013301471 @default.
- W2313012562 creator A5026179250 @default.
- W2313012562 creator A5028964368 @default.
- W2313012562 creator A5030899018 @default.
- W2313012562 creator A5038493219 @default.
- W2313012562 creator A5039016354 @default.
- W2313012562 creator A5072895470 @default.
- W2313012562 creator A5091034571 @default.
- W2313012562 creator A5091475285 @default.
- W2313012562 creator A5091548965 @default.
- W2313012562 date "2016-03-29" @default.
- W2313012562 modified "2023-10-18" @default.
- W2313012562 title "The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy" @default.
- W2313012562 cites W174512763 @default.
- W2313012562 cites W1969717239 @default.
- W2313012562 cites W1971982923 @default.
- W2313012562 cites W1973313311 @default.
- W2313012562 cites W1990374465 @default.
- W2313012562 cites W2027178882 @default.
- W2313012562 cites W2027264255 @default.
- W2313012562 cites W2035494240 @default.
- W2313012562 cites W2036272929 @default.
- W2313012562 cites W2039398620 @default.
- W2313012562 cites W2039854804 @default.
- W2313012562 cites W2042753415 @default.
- W2313012562 cites W2048813343 @default.
- W2313012562 cites W2051406887 @default.
- W2313012562 cites W2053816472 @default.
- W2313012562 cites W2053821542 @default.
- W2313012562 cites W2061963189 @default.
- W2313012562 cites W2073408049 @default.
- W2313012562 cites W2073927780 @default.
- W2313012562 cites W2075282559 @default.
- W2313012562 cites W2082714048 @default.
- W2313012562 cites W2086117054 @default.
- W2313012562 cites W2088658807 @default.
- W2313012562 cites W2104174115 @default.
- W2313012562 cites W2108083474 @default.
- W2313012562 cites W2109041435 @default.
- W2313012562 cites W2109934828 @default.
- W2313012562 cites W2109972881 @default.
- W2313012562 cites W2111331733 @default.
- W2313012562 cites W2113284991 @default.
- W2313012562 cites W2114366598 @default.
- W2313012562 cites W2116041125 @default.
- W2313012562 cites W2122157959 @default.
- W2313012562 cites W2132871071 @default.
- W2313012562 cites W2138581343 @default.
- W2313012562 cites W2154471160 @default.
- W2313012562 cites W2160683202 @default.
- W2313012562 cites W2163388642 @default.
- W2313012562 cites W2164356078 @default.
- W2313012562 cites W2165377952 @default.
- W2313012562 cites W2169723296 @default.
- W2313012562 cites W4232767515 @default.
- W2313012562 cites W4292400027 @default.
- W2313012562 doi "https://doi.org/10.1038/ncomms11074" @default.
- W2313012562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4820544" @default.
- W2313012562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27020607" @default.
- W2313012562 hasPublicationYear "2016" @default.
- W2313012562 type Work @default.
- W2313012562 sameAs 2313012562 @default.
- W2313012562 citedByCount "50" @default.
- W2313012562 countsByYear W23130125622016 @default.
- W2313012562 countsByYear W23130125622017 @default.
- W2313012562 countsByYear W23130125622018 @default.
- W2313012562 countsByYear W23130125622019 @default.
- W2313012562 countsByYear W23130125622020 @default.
- W2313012562 countsByYear W23130125622021 @default.
- W2313012562 countsByYear W23130125622022 @default.
- W2313012562 countsByYear W23130125622023 @default.
- W2313012562 crossrefType "journal-article" @default.
- W2313012562 hasAuthorship W2313012562A5006822602 @default.
- W2313012562 hasAuthorship W2313012562A5013301471 @default.
- W2313012562 hasAuthorship W2313012562A5026179250 @default.
- W2313012562 hasAuthorship W2313012562A5028964368 @default.
- W2313012562 hasAuthorship W2313012562A5030899018 @default.
- W2313012562 hasAuthorship W2313012562A5038493219 @default.
- W2313012562 hasAuthorship W2313012562A5039016354 @default.
- W2313012562 hasAuthorship W2313012562A5072895470 @default.
- W2313012562 hasAuthorship W2313012562A5091034571 @default.
- W2313012562 hasAuthorship W2313012562A5091475285 @default.
- W2313012562 hasAuthorship W2313012562A5091548965 @default.
- W2313012562 hasBestOaLocation W23130125621 @default.
- W2313012562 hasConcept C134018914 @default.
- W2313012562 hasConcept C167414201 @default.
- W2313012562 hasConcept C170493617 @default.
- W2313012562 hasConcept C181199279 @default.
- W2313012562 hasConcept C185592680 @default.
- W2313012562 hasConcept C207200792 @default.
- W2313012562 hasConcept C23265538 @default.
- W2313012562 hasConcept C2778271984 @default.
- W2313012562 hasConcept C3018791406 @default.
- W2313012562 hasConcept C51705589 @default.
- W2313012562 hasConcept C55493867 @default.
- W2313012562 hasConcept C7876069 @default.
- W2313012562 hasConcept C86803240 @default.