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- W2313066715 abstract "A number of authors123456 have described the vasopressor effect of large doses of normally vasodilator choline derivatives in atropinized animals, including the “parasympathetic substance’ acetylcholine. The findings of Hunt7 and Broun and Beaune8 on these subjects will be discussed in a detailed paper.All drugs used in these experiments were given intravenously and the doses expressed in milligrams per kg. In 6 cats, 4 rabbits and 10 dogs anesthetized with barbiturates, it was found that acetylcholine in doses of 0.05 to 0.1 mg. did not produce vasopressor effects following the administration of 2 to 5 mg. of atropine sulphate. If the administration of acetylcholine was preceded by 0.3 to 2 mg. of physostigmine salicylate in atropinized animals, acetylcholine produced sharp, epinephrine-like rises in the blood pressure of 50 to 100 mm. of Hg. in cats and dogs, and lesser rises in rabbits. These pressor effects with acetylcholine may be elicited many times over a period of 6 hours in atropinized animals f..." @default.
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- W2313066715 date "1936-12-01" @default.
- W2313066715 modified "2023-09-24" @default.
- W2313066715 title "Further Studies on Action of Physostigmine on Autonomic Ganglia" @default.
- W2313066715 doi "https://doi.org/10.3181/00379727-35-8980p" @default.
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