FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313078833> ?p ?o ?g. }

• W2313078833 endingPage "422" @default.
• W2313078833 startingPage "422" @default.
• W2313078833 abstract "Several electron scavengers that irreversibly form potential hydrogen-abstracting species upon one-electron reduction have been tested as agents for conversion of reductive damage to DNA bases into damage to the sugar-phosphate backbone. Electron spin resonance spectroscopy is employed to follow the production of radicals and transformations after irradiation. The scavengers tested included neutral (acrylamide, iodoacetamide) and cationic [triphenylsulfonium (Ph3S+), o,o'-diphenylenebromonium (DPB) and o,o'-diphenyleneiodonium (DPI)] compounds. Modification of reductive radiation damage in DNA is found to occur by scavenging of initial mobile electrons at low temperatures as well as thermally activated electron transfer from DNA electron-gain centers upon annealing. Electron transfer from the bases to hydrogen-bonded acrylamide has the smallest activation energy among other scavengers but produces a secondary alkyl radical incapable of abstracting hydrogen from the sugar-phosphate backbone. A primary alkyl radical generated from iodoacetamide has been shown to abstract preferentially from the thymine methyl group but not from deoxyribose moieties. Aryl radicals generated from aromatic onium salts such as Ph3S+, and especially DPI and DPB, are found to be the agents which best abstract hydrogen atoms from the deoxyribose portion of DNA. The use of DPB and DPI as radiation modifiers allows the elimination of undesirable side reactions of aryl radicals and through hydrogen abstraction results in high yields of a species identified as the DNA C1'. sugar radical. The second reaction pathway found for DPI and DPB in DNA is addition of an aryl radical to the thymine 5,6 double bond. Cysteamine is shown to preferentially eliminate sugar radicals upon annealing and to have little impact on the thermal stability of the thymine adduct radical." @default.
• W2313078833 created "2016-06-24" @default.
• W2313078833 creator A5037234901 @default.
• W2313078833 creator A5061668281 @default.
• W2313078833 creator A5067706954 @default.
• W2313078833 date "1998-05-01" @default.
• W2313078833 modified "2023-09-25" @default.
• W2313078833 title "Modification of the Reductive Pathway in Gamma-Irradiated DNA by Electron Scavengers: Targeting the Sugar-Phosphate Backbone" @default.
• W2313078833 cites W1519035545 @default.
• W2313078833 cites W1520315220 @default.
• W2313078833 cites W1887520422 @default.
• W2313078833 cites W1895145214 @default.
• W2313078833 cites W1901862329 @default.
• W2313078833 cites W1926950498 @default.
• W2313078833 cites W1963734152 @default.
• W2313078833 cites W1965607533 @default.
• W2313078833 cites W1969936130 @default.
• W2313078833 cites W1970163738 @default.
• W2313078833 cites W1977637439 @default.
• W2313078833 cites W1983896059 @default.
• W2313078833 cites W1985062436 @default.
• W2313078833 cites W1987709463 @default.
• W2313078833 cites W1995696616 @default.
• W2313078833 cites W2008644646 @default.
• W2313078833 cites W2011729333 @default.
• W2313078833 cites W2012269979 @default.
• W2313078833 cites W2013989300 @default.
• W2313078833 cites W2019959914 @default.
• W2313078833 cites W2020540440 @default.
• W2313078833 cites W2023219008 @default.
• W2313078833 cites W2025557975 @default.
• W2313078833 cites W2026848167 @default.
• W2313078833 cites W2028165700 @default.
• W2313078833 cites W2028678385 @default.
• W2313078833 cites W2032173016 @default.
• W2313078833 cites W2036456525 @default.
• W2313078833 cites W2039157713 @default.
• W2313078833 cites W2053790311 @default.
• W2313078833 cites W2053941895 @default.
• W2313078833 cites W2058571522 @default.
• W2313078833 cites W2061272221 @default.
• W2313078833 cites W2061885535 @default.
• W2313078833 cites W2067224675 @default.
• W2313078833 cites W2074819208 @default.
• W2313078833 cites W2078302399 @default.
• W2313078833 cites W2085806547 @default.
• W2313078833 cites W2088748048 @default.
• W2313078833 cites W2091349715 @default.
• W2313078833 cites W2104847120 @default.
• W2313078833 cites W2115989447 @default.
• W2313078833 cites W2122984989 @default.
• W2313078833 cites W2144619212 @default.
• W2313078833 cites W2152480361 @default.
• W2313078833 cites W2197255216 @default.
• W2313078833 cites W2313576982 @default.
• W2313078833 cites W2314143352 @default.
• W2313078833 cites W2315138116 @default.
• W2313078833 cites W2318550174 @default.
• W2313078833 cites W2325484026 @default.
• W2313078833 cites W2325934889 @default.
• W2313078833 cites W2332413560 @default.
• W2313078833 cites W2333860896 @default.
• W2313078833 cites W2415852505 @default.
• W2313078833 cites W2416497036 @default.
• W2313078833 cites W2433795512 @default.
• W2313078833 cites W2505695962 @default.
• W2313078833 cites W2603259969 @default.
• W2313078833 cites W2898668825 @default.
• W2313078833 cites W2951602852 @default.
• W2313078833 cites W2461500974 @default.
• W2313078833 doi "https://doi.org/10.2307/3579781" @default.
• W2313078833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9588352" @default.
• W2313078833 hasPublicationYear "1998" @default.
• W2313078833 type Work @default.
• W2313078833 sameAs 2313078833 @default.
• W2313078833 citedByCount "19" @default.
• W2313078833 countsByYear W23130788332012 @default.
• W2313078833 countsByYear W23130788332021 @default.
• W2313078833 countsByYear W23130788332023 @default.
• W2313078833 crossrefType "journal-article" @default.
• W2313078833 hasAuthorship W2313078833A5037234901 @default.
• W2313078833 hasAuthorship W2313078833A5061668281 @default.
• W2313078833 hasAuthorship W2313078833A5067706954 @default.
• W2313078833 hasConcept C139066938 @default.
• W2313078833 hasConcept C178790620 @default.
• W2313078833 hasConcept C185592680 @default.
• W2313078833 hasConcept C2776858809 @default.
• W2313078833 hasConcept C2777132085 @default.
• W2313078833 hasConcept C2777709666 @default.
• W2313078833 hasConcept C2780535078 @default.
• W2313078833 hasConcept C552990157 @default.
• W2313078833 hasConcept C55493867 @default.
• W2313078833 hasConcept C66887884 @default.
• W2313078833 hasConcept C75473681 @default.
• W2313078833 hasConcept C81022585 @default.
• W2313078833 hasConceptScore W2313078833C139066938 @default.
• W2313078833 hasConceptScore W2313078833C178790620 @default.
• W2313078833 hasConceptScore W2313078833C185592680 @default.

• next