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• W2313091786 abstract "Background Current screening guidelines for malaria in new refugees include a combination of thick and thin film examination and immunochromatographic antigen test (ICT)1. However, as the prevalence of malaria in our population has decreased due to changing refugee demographics,2,3 an immunochromatographic antigen test (ICT) alone may be sufficient to exclude malaria in asymptomatic patients. Aim To determine if an ICT alone can reliably exclude malaria in our asymptomatic refugee population. Methods A retrospective analysis was conducted of all investigations for malaria performed from 01/08/2011 to 31/07/2013, including external morphological and PCR validation where applicable. Results 45 of 1248 (3.6%) patients investigated were diagnosed with malaria, all cases were in symptomatic patients. Overall 42/45 malaria cases were detected by the BinaxNOW ICT; sensitivity (95%CI) 93.3% (80.7-98.3%) and negative predictive value (NPV) 99.8% (99.2-99.9%). All 21 cases of Plasmodium falciparum were detected; sensitivity and NPV of 100% (80.8-100%) and 100% (99.6-100%), respectively. ICT detected 18/20 cases of P. vivax; sensitivity and negative predictive value of 90.9% (69.4%-98.4%) and 99.8% (99.3%-100%), respectively. Too few cases of P. malariae and no cases of P. ovale or P. knowlesis were diagnosed for adequate assessment. Discussion These data suggest that an ICT alone may be sufficient for malaria screening in our asymptomatic refugee population. Current screening guidelines for malaria in new refugees include a combination of thick and thin film examination and immunochromatographic antigen test (ICT)1. However, as the prevalence of malaria in our population has decreased due to changing refugee demographics,2,3 an immunochromatographic antigen test (ICT) alone may be sufficient to exclude malaria in asymptomatic patients. To determine if an ICT alone can reliably exclude malaria in our asymptomatic refugee population. A retrospective analysis was conducted of all investigations for malaria performed from 01/08/2011 to 31/07/2013, including external morphological and PCR validation where applicable. 45 of 1248 (3.6%) patients investigated were diagnosed with malaria, all cases were in symptomatic patients. Overall 42/45 malaria cases were detected by the BinaxNOW ICT; sensitivity (95%CI) 93.3% (80.7-98.3%) and negative predictive value (NPV) 99.8% (99.2-99.9%). All 21 cases of Plasmodium falciparum were detected; sensitivity and NPV of 100% (80.8-100%) and 100% (99.6-100%), respectively. ICT detected 18/20 cases of P. vivax; sensitivity and negative predictive value of 90.9% (69.4%-98.4%) and 99.8% (99.3%-100%), respectively. Too few cases of P. malariae and no cases of P. ovale or P. knowlesis were diagnosed for adequate assessment. These data suggest that an ICT alone may be sufficient for malaria screening in our asymptomatic refugee population." @default.
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• W2313091786 date "2014-01-01" @default.
• W2313091786 modified "2023-09-26" @default.
• W2313091786 title "Asymptomatic refugee malaria screening - implications of using a rapid immunochromatographic antigen test only: retrospective analysis of 1248 patients" @default.
• W2313091786 cites W2152091751 @default.
• W2313091786 doi "https://doi.org/10.1097/01.pat.0000443517.33625.e3" @default.
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