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- W2313100515 abstract "Besides doxorubicin's (DOX) well known cardiotoxic effects, it is associated with irreversible testicular damage. In an attempt to preserve testicular function during DOX treatment, androgen deprivation therapy (ADT) using goserelin acetate is gaining clinical popularity as it temporarily suppresses gonadal function thereby minimizing DOX's gonadal damage. However, DOX's cardiac dysfunction is a major clinical concern as well, and evidence suggests that ADT may exacerbate DOX-induced cardiac dysfunction. Exercise has been shown to protect against DOX-induced cardiac dysfunction, but the effects of exercise on cardiac function during combined ADT and DOX treatment are currently unknown. PURPOSE: To determine whether exercise training can attenuate the combined cardiotoxic effects of ADT and DOX. METHODS: Male Sprague Dawley rats were randomly assigned to experimental groups: control implants (CON), androgen deprivation therapy (ADT), doxorubicin (DOX), or (ADT+DOX). Animals received ADT or control implants on day 1 and 29 of the 56 day protocol. Animals were then assigned to either sedentary activity (SED) or forced treadmill endurance exercise (TM). Exercise commenced the day after initial implants. On day 15, animals received 1 mg/kg/d DOX i.p. for 10 consecutive days or an equivalent volume of 0.9% saline. On day 57, cardiac function was assessed using an isolated perfused working heart model. RESULTS: When compared to sedentary CON, DOX and ADT+DOX treated animals possessed significantly depressed left ventricular developed pressure (-21% and -27%, respectively, P<0.05), maximal rate of pressure development (-29% and -32%, respectively, P<0.05), and maximal rate of pressure decline (25% and 31%, respectively, P<0.05). Exercise training during ADT+DOX treatment, however, attenuated the depression in left ventricular developed pressure, maximal rate of pressure development, and maximal rate of pressure decline (-9%, -8%, and 2%, respectively when compared to CON, P>0.05). CONCLUSIONS: Treadmill training protected against combined ADT+DOX dysfunction, suggesting that cardiac function can be preserved in the clinical setting if cancer survivors concurrently endurance train while undergoing ADT and DOX treatment." @default.
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- W2313100515 date "2011-05-01" @default.
- W2313100515 modified "2023-10-16" @default.
- W2313100515 title "Endurance Exercise Attenuates Cardiotoxicity Induced by Androgen Deprivation and Doxorubicin" @default.
- W2313100515 doi "https://doi.org/10.1249/01.mss.0000401832.85707.00" @default.
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