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- W2313117816 endingPage "567" @default.
- W2313117816 startingPage "553" @default.
- W2313117816 abstract "Diagnostic strategies, particularly non-invasive blood-based screening approaches, are gaining increased attention for the early detection and attenuation of mortality associated with colorectal cancer (CRC). However, the majority of current screening approaches are inadequate at replacing the conventional CRC diagnostic procedures. Yet, due to technological advances and better understanding of molecular events underlying human cancer, a new category of biomarkers are on the horizon. Recent evidence indicates that cells release a distinct class of small vesicles called ‘exosomes’, which contain nucleic acids and proteins that reflect and typify host-cell molecular architecture. Intriguingly, exosomes released from cancer cells have a distinct genetic and epigenetic makeup, which allows them to undertake their tumorigenic function. From a clinical standpoint, these unique cancer-specific fingerprints present in exosomes appear to be detectable in a small amount of blood, making them very attractive substrates for developing cancer biomarkers, particularly noninvasive diagnostic approaches." @default.
- W2313117816 created "2016-06-24" @default.
- W2313117816 creator A5008862399 @default.
- W2313117816 creator A5056635710 @default.
- W2313117816 creator A5080837446 @default.
- W2313117816 date "2016-03-16" @default.
- W2313117816 modified "2023-10-18" @default.
- W2313117816 title "Exosomal microRNA Biomarkers: Emerging Frontiers in Colorectal and Other Human Cancers" @default.
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