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• W2313141987 abstract "Intravenously injected microbubbles (MBs) can be utilized as ultrasound contrast agent (CA) resulting in enhanced image quality. A novel CA, consisting of air filled MBs stabilized with a shell of polyvinyl alcohol (PVA) has been developed. These spherical MBs have been decorated with superparamagnetic iron oxide nanoparticles (SPIONs) in order to serve as both ultrasound and magnetic resonance imaging (MRI) CA. In this study, a mathematical model was introduced that determined the shell thickness of two types of SPIONs decorated MBs (Type A and Type B). The shell thickness of MBs is important to determine, as it affects the acoustical properties. In order to investigate the shell thickness, thin sections of plastic embedded MBs were prepared and imaged using transmission electron microscopy (TEM). However, the sections were cut at random distances from the MB center, which affected the observed shell thickness. Hence, the model determined the average shell thickness of the MBs from corrected mean values of the outer and inner radii observed in the TEM sections. The model was validated using simulated slices of MBs with known shell thickness and radius. The average shell thickness of Type A and Type B MBs were 651 nm and 637 nm, respectively." @default.
• W2313141987 created "2016-06-24" @default.
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• W2313141987 creator A5062217893 @default.
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• W2313141987 date "2016-06-01" @default.
• W2313141987 modified "2023-10-01" @default.
• W2313141987 title "Shell thickness determination of polymer-shelled microbubbles using transmission electron microscopy" @default.
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• W2313141987 doi "https://doi.org/10.1016/j.micron.2016.03.009" @default.
• W2313141987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27077316" @default.
• W2313141987 hasPublicationYear "2016" @default.
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