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- W2313159643 abstract "Nearly all attempts to understand and predict response of patient cancer cells to therapeutics rely on measurements of static properties at a single time point such as protein abundance, gene expression profiling, or genetic code. While these approaches have doubtless yielded useful information to guide therapy, it is often the case that observing how a system responds to systematic perturbation can be a more powerful guide to understanding and predicting behavior. Using BH3 profiling, we systematically perturb the mitochondria of cancer cells with BH3 peptides and can make predictions about response to therapy based on the response observed. So far, we have successfully applied BH3 profiling to understanding and predicting clinical response to conventional chemotherapy, targeted pathway inhibitors and direct inhibitors of anti-apoptotic proteins like BCL-2. Since BH3 profiling can provide results within a single day, it is applicable to studying primary cancer cells from patient biopsies without the need for prolonged ex vivo culture. BH3 profiling has the potential to provide a predictive biomarker for any cancer therapeutic that kills cancer cells via the mitochondrial pathway of apoptosis. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):CN04-01. Citation Format: Joan Montero, Triona Ni Chonghaile, Kris Sarosiek, Jeremy A. Ryan, Hogdal Leah, Anthony G. Letai. Poking cancer cells with BH3 profiling to personalize cancer therapy. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr CN04-01." @default.
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- W2313159643 date "2013-11-01" @default.
- W2313159643 modified "2023-10-15" @default.
- W2313159643 title "Abstract CN04-01: Poking cancer cells with BH3 profiling to personalize cancer therapy." @default.
- W2313159643 doi "https://doi.org/10.1158/1535-7163.targ-13-cn04-01" @default.
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