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• W2313182027 endingPage "984" @default.
• W2313182027 startingPage "979" @default.
• W2313182027 abstract "Metabolic engineering was applied to the development of Escherichia coli capable of synthesizing tyrosol (2-(4-hydroxyphenyl)ethanol), an attractive phenolic compound with great industrial value, from glucose, a renewable carbon source. In this strain, tyrosine, which was supplied not only from the culture medium but also from the central metabolism, was converted into tyrosol via three steps: decarboxylation, amine oxidation, and reduction. The engineered strain synthesized both tyrosol and 4-hydroxyphenylacetate (4HPA), but disruption of the endogenous phenylacetaldehyde dehydrogenase gene shut off 4HPA production and improved the production of tyrosol as a sole product. The engineered mutant strain was capable of producing 0.5 mM tyrosol from 1% (w/v) glucose during a 48 h shake flask cultivation." @default.
• W2313182027 created "2016-06-24" @default.
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• W2313182027 date "2012-01-20" @default.
• W2313182027 modified "2023-10-17" @default.
• W2313182027 title "Engineering of a Tyrosol-Producing Pathway, Utilizing Simple Sugar and the Central Metabolic Tyrosine, in Escherichia coli" @default.
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• W2313182027 doi "https://doi.org/10.1021/jf203256f" @default.
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