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• W2313202297 endingPage "8693" @default.
• W2313202297 startingPage "8683" @default.
• W2313202297 abstract "Development of high-stability and efficient nonviral vectors with low cytoxicity is important for targeted tumor gene therapy. In this study, cationic polymeric liposomes (CPLs), with similar lipid bilayer structure and high thermal stability, were prepared from polymeric surfactants of quaternized (carboxymethyl)chitosan with different carbon chains (dodecyl, tetradecyl, hexadecyl, and octadecyl). By comparing different factors that influence gene delivery, tetradecyl-quaternized (carboxymethy)chitosan (TQCMC) CPLs, with suitable size (184.4 ± 17.1 nm), ζ potentials (27.5 ± 4.9 mV), and productivity for synthesis TQCMC (weight yield 13.1%), were selected for gene transfection evaluation in various cancer cell lines. Although TQCMC CPLs have lower gene transfection efficiency compared with cationic liposomes (Lipofectamine 2000) in vitro, they displayed higher reporter gene delivery ability for cancer tissues (bearing U87 and SMMC-7721 tumors) in vivo after intravenous injection. TQCMC CPLs also have lower cell cytotoxicity and lower cytokine production or liver injury for BALB/c mice. We conclude that the CPLs are promising gene delivery systems that may be used to target various cancers." @default.
• W2313202297 created "2016-06-24" @default.
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• W2313202297 creator A5062518024 @default.
• W2313202297 creator A5071574867 @default.
• W2313202297 creator A5082020327 @default.
• W2313202297 date "2013-06-27" @default.
• W2313202297 modified "2023-10-14" @default.
• W2313202297 title "Properties and Evaluation of Quaternized Chitosan/Lipid Cation Polymeric Liposomes for Cancer-Targeted Gene Delivery" @default.
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• W2313202297 doi "https://doi.org/10.1021/la401166v" @default.
• W2313202297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23763489" @default.
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