Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313207833> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2313207833 endingPage "581" @default.
- W2313207833 startingPage "572" @default.
- W2313207833 abstract "Abstract In this study, carboxylated quercetin (CQ) was conjugated to superparamagnetic iron oxide nanoparticles (SPIONs) which were modified by (3-aminopropyl) triethoxysilane (APTES), Folic acid (FA) and carboxylated Polyethylene glycol (PEG); (SPION@APTES@FA-PEG@CQ), nanodrug has been synthesized via polyol and accompanying by various chemical synthesis routes. The characterization of the final product was done via X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Thermal gravimetric analysis (TGA), Transmission electron spectroscopy (TEM) and Vibrating sample magnetometer (VSM). Its cytotoxic and apoptotic activities on over expressed folic acid receptor (FR + ) (MCF-7, HeLa) and none expressed folic acid receptor (FR-) (A549) cancer cell lines were determined by using MTT assay, Real-Time Cell Analysis, TUNEL assay, Annexin assay and RT-PCR analysis for Caspase3/7 respectively. SPION@APTES@FA-PEG@CQ nanodrug showed higher cytotoxicity against HeLa and MCF-7 cell lines as compared with A549 cell line. Moreover, SPION@APTES@FA-PEG@CQ nanodrug also caused higher apoptotic and necrotic effects in 100 μg/mL HeLa and MCF-7 cells than A549 cells. The findings showed that SPION@APTES@FA-PEG@CQ nanodrug has cytotoxic, apoptotic and necrotic effects on HeLa and MCF-7 which are FR over expressed cell lines and can be potentially used for the delivery of quercetin to cervical and breast cancer cells." @default.
- W2313207833 created "2016-06-24" @default.
- W2313207833 creator A5058197843 @default.
- W2313207833 creator A5062950007 @default.
- W2313207833 creator A5071324170 @default.
- W2313207833 date "2016-08-01" @default.
- W2313207833 modified "2023-09-25" @default.
- W2313207833 title "Biomedical applications of SPION@APTES@PEG-folic acid@carboxylated quercetin nanodrug on various cancer cells" @default.
- W2313207833 cites W1968143647 @default.
- W2313207833 cites W1968627984 @default.
- W2313207833 cites W1995980440 @default.
- W2313207833 cites W2013008946 @default.
- W2313207833 cites W2015442009 @default.
- W2313207833 cites W2016487646 @default.
- W2313207833 cites W2028412605 @default.
- W2313207833 cites W2040116920 @default.
- W2313207833 cites W2047271327 @default.
- W2313207833 cites W2051376250 @default.
- W2313207833 cites W2056644518 @default.
- W2313207833 cites W2085637207 @default.
- W2313207833 cites W2087032263 @default.
- W2313207833 cites W2092252646 @default.
- W2313207833 cites W2123559008 @default.
- W2313207833 cites W2136365615 @default.
- W2313207833 cites W2159320182 @default.
- W2313207833 cites W2177900183 @default.
- W2313207833 cites W2289150773 @default.
- W2313207833 doi "https://doi.org/10.1016/j.apsusc.2016.03.217" @default.
- W2313207833 hasPublicationYear "2016" @default.
- W2313207833 type Work @default.
- W2313207833 sameAs 2313207833 @default.
- W2313207833 citedByCount "36" @default.
- W2313207833 countsByYear W23132078332016 @default.
- W2313207833 countsByYear W23132078332017 @default.
- W2313207833 countsByYear W23132078332018 @default.
- W2313207833 countsByYear W23132078332019 @default.
- W2313207833 countsByYear W23132078332020 @default.
- W2313207833 countsByYear W23132078332021 @default.
- W2313207833 countsByYear W23132078332022 @default.
- W2313207833 countsByYear W23132078332023 @default.
- W2313207833 crossrefType "journal-article" @default.
- W2313207833 hasAuthorship W2313207833A5058197843 @default.
- W2313207833 hasAuthorship W2313207833A5062950007 @default.
- W2313207833 hasAuthorship W2313207833A5071324170 @default.
- W2313207833 hasConcept C10138342 @default.
- W2313207833 hasConcept C126322002 @default.
- W2313207833 hasConcept C162324750 @default.
- W2313207833 hasConcept C185592680 @default.
- W2313207833 hasConcept C2778004101 @default.
- W2313207833 hasConcept C2781263971 @default.
- W2313207833 hasConcept C2992130864 @default.
- W2313207833 hasConcept C54400483 @default.
- W2313207833 hasConcept C55493867 @default.
- W2313207833 hasConcept C71924100 @default.
- W2313207833 hasConceptScore W2313207833C10138342 @default.
- W2313207833 hasConceptScore W2313207833C126322002 @default.
- W2313207833 hasConceptScore W2313207833C162324750 @default.
- W2313207833 hasConceptScore W2313207833C185592680 @default.
- W2313207833 hasConceptScore W2313207833C2778004101 @default.
- W2313207833 hasConceptScore W2313207833C2781263971 @default.
- W2313207833 hasConceptScore W2313207833C2992130864 @default.
- W2313207833 hasConceptScore W2313207833C54400483 @default.
- W2313207833 hasConceptScore W2313207833C55493867 @default.
- W2313207833 hasConceptScore W2313207833C71924100 @default.
- W2313207833 hasLocation W23132078331 @default.
- W2313207833 hasOpenAccess W2313207833 @default.
- W2313207833 hasPrimaryLocation W23132078331 @default.
- W2313207833 hasRelatedWork W2001138376 @default.
- W2313207833 hasRelatedWork W2028538946 @default.
- W2313207833 hasRelatedWork W2060084080 @default.
- W2313207833 hasRelatedWork W2070209162 @default.
- W2313207833 hasRelatedWork W2138673273 @default.
- W2313207833 hasRelatedWork W2313207833 @default.
- W2313207833 hasRelatedWork W2333469679 @default.
- W2313207833 hasRelatedWork W2342275039 @default.
- W2313207833 hasRelatedWork W2977548354 @default.
- W2313207833 hasRelatedWork W1958303997 @default.
- W2313207833 hasVolume "378" @default.
- W2313207833 isParatext "false" @default.
- W2313207833 isRetracted "false" @default.
- W2313207833 magId "2313207833" @default.
- W2313207833 workType "article" @default.