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- W2313223816 abstract "Various kinds of the neoglycolipids, composed of N-acethylgalactosamine(GalNAc), a spacer arm and a lipid, were synthesized to modify the surface of liposomes and to investigate the distribution of the liposomes. The neoglycolipids, having octamethylene as a spacer arm, are only slightly soluble in various kind of solvents. However, by using tricthyleneglycol as a spacer arm, the solubility of the neoglycolipid was greatly improved without loss of the affinity towards hepatocyte in vivo. Liposomes modified with the neoglycolipid, which contained the branched lipid as an anchor, showed remarkable accumulation in the liver. However, liposomes modified with the straight chain lipid as an anchor showed the same accumulation in the liver as the control liposomes. The accumulation depends on the structure of the anchor part of the neoglycolipids. We synthesized the neoglycolipid, which contained three GalNAc residue, branched with L-glutamyl-L-glutamic acid (clustered GalNAc derivative). The clustered GalNAc derivative showed higher affinity towards hepatocyte than unclustered GalNAc derivative in vitro. The liposomes modified with the clustered GaINAc derivative were disappeared faster from plasma and accumulated more in the liver than the control liposomes after intravenous injection to rats. Although the accumulation of clustered GalNAc derivative coated liposomes in the liver was the same extent as the accumulation of non clustered GalNAc derivative modified liposomes. So cluster effect was not observed in in vivo examination." @default.
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- W2313223816 date "1996-01-01" @default.
- W2313223816 modified "2023-09-26" @default.
- W2313223816 title "Synthesis and evaluation of neoglycolipid for liposome modification." @default.
- W2313223816 doi "https://doi.org/10.2745/dds.11.91" @default.
- W2313223816 hasPublicationYear "1996" @default.
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