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- W2313225462 abstract "Poised (bivalent) chromatin is defined by the simultaneous presence of histone modifications associated with both gene activation and repression. This epigenetic feature was first observed at promoters of lineage-specific regulatory genes in embryonic stem cells in culture. More recent work has shown that, in vivo, mammalian germ cells maintain poised chromatin at promoters of many genes that regulate somatic development, and that they retain this state from fetal stages through meiosis and gametogenesis. We hypothesize that the poised chromatin state is essential for germ cell identity and function. We propose three roles for poised chromatin in the mammalian germ line: prevention of DNA methylation, maintenance of germ cell identity and preparation for totipotency. We discuss these roles in the context of recently proposed models for germline potency and epigenetic inheritance." @default.
- W2313225462 created "2016-06-24" @default.
- W2313225462 creator A5052408115 @default.
- W2313225462 creator A5069145017 @default.
- W2313225462 date "2014-10-01" @default.
- W2313225462 modified "2023-10-11" @default.
- W2313225462 title "Poised chromatin in the mammalian germ line" @default.
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- W2313225462 doi "https://doi.org/10.1242/dev.113027" @default.
- W2313225462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4197577" @default.
- W2313225462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25249456" @default.
- W2313225462 hasPublicationYear "2014" @default.
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