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• W2313230150 endingPage "8460" @default.
• W2313230150 startingPage "8452" @default.
• W2313230150 abstract "The development of strategies to couple biomolecules covalently to surfaces is necessary for constructing sensing arrays for biological and biomedical applications. One attractive conjugation reaction is hydrazone formation—the reaction of a hydrazine with an aldehyde or ketone—as both hydrazines and aldehydes/ketones are largely bioorthogonal, which makes this particular reaction suitable for conjugating biomolecules to a variety of substrates. We show that the mild reaction conditions afforded by hydrazone conjugation enable the conjugation of DNA and proteins to the substrate surface in significantly higher yields than can be achieved with traditional bioconjugation techniques, such as maleimide chemistry. Next, we designed and synthesized a photocaged aryl ketone that can be conjugated to a surface and photochemically activated to provide a suitable partner for subsequent hydrazone formation between the surface-anchored ketone and DNA- or protein-hydrazines. Finally, we exploit the latent functionality of the photocaged ketone and pattern multiple biomolecules on the same substrate, effectively demonstrating a strategy for designing substrates with well-defined domains of different biomolecules. We expect that this approach can be extended to the production of multiplexed assays by using an appropriate mask with sequential photoexposure and biomolecule conjugation steps." @default.
• W2313230150 created "2016-06-24" @default.
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• W2313230150 date "2014-07-09" @default.
• W2313230150 modified "2023-09-25" @default.
• W2313230150 title "High-Yielding and Photolabile Approaches to the Covalent Attachment of Biomolecules to Surfaces via Hydrazone Chemistry" @default.
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• W2313230150 doi "https://doi.org/10.1021/la500744s" @default.
• W2313230150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24972257" @default.
• W2313230150 hasPublicationYear "2014" @default.
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