FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313233463> ?p ?o ?g. }

• W2313233463 endingPage "797" @default.
• W2313233463 startingPage "788" @default.
• W2313233463 abstract "Bortezomib is an anti-cancer agent that induces ER stress by inhibiting proteasomal degradation. However, the effects of bortezomib appear to be dependent on its concentration and cellular context. Since ER stress is closely related to type 2 diabetes, the authors examined the effects of bortezomib on palmitic acid (PA)-induced ER stress in C2C12 murine myotubes. At low concentrations (<20nM), bortezomib protected myotubes from PA (750μM)-induced ER stress and inflammation. Either tunicamycin or thapsigargin-induced ER stress was also reduced by bortezomib. In addition, reduced glucose uptake and Akt phosphorylation induced by PA were prevented by co-treating bortezomib (10nM) both in the presence or absence of insulin. These protective effects of bortezomib were found to be associated with reduced JNK phosphorylation. Furthermore, bortezomib-induced AMPK phosphorylation, and the protective effects of bortezomib were diminished by AMPK knockdown, suggesting that AMPK activation underlies the effects of bortezomib. The in vivo administration of bortezomib at nontoxic levels (at 50 or 200μg/kg, i.p.) twice weekly for 5weeks to ob/ob mice improved insulin resistance, increased AMPK phosphorylation, reduced ER stress marker levels, and JNK inhibition in skeletal muscle. The study shows that bortezomib reduces ER stress, inflammation, and insulin resistance in vitro and in vivo, and suggests that bortezomib has novel applications for the treatment of metabolic disorders." @default.
• W2313233463 created "2016-06-24" @default.
• W2313233463 creator A5016933435 @default.
• W2313233463 creator A5027142320 @default.
• W2313233463 creator A5029430341 @default.
• W2313233463 creator A5043503859 @default.
• W2313233463 creator A5080191880 @default.
• W2313233463 creator A5084844851 @default.
• W2313233463 date "2016-08-01" @default.
• W2313233463 modified "2023-09-23" @default.
• W2313233463 title "Bortezomib attenuates palmitic acid-induced ER stress, inflammation and insulin resistance in myotubes via AMPK dependent mechanism" @default.
• W2313233463 cites W1970420856 @default.
• W2313233463 cites W1972041619 @default.
• W2313233463 cites W1972271433 @default.
• W2313233463 cites W1978698026 @default.
• W2313233463 cites W1984413737 @default.
• W2313233463 cites W1988360928 @default.
• W2313233463 cites W2002207827 @default.
• W2313233463 cites W2018135697 @default.
• W2313233463 cites W2021242983 @default.
• W2313233463 cites W2025574928 @default.
• W2313233463 cites W2026642838 @default.
• W2313233463 cites W2027021131 @default.
• W2313233463 cites W2033150364 @default.
• W2313233463 cites W2035324964 @default.
• W2313233463 cites W2048456744 @default.
• W2313233463 cites W2049374802 @default.
• W2313233463 cites W2053154947 @default.
• W2313233463 cites W2071073097 @default.
• W2313233463 cites W2074549465 @default.
• W2313233463 cites W2078044922 @default.
• W2313233463 cites W2083853346 @default.
• W2313233463 cites W2084681270 @default.
• W2313233463 cites W2089040522 @default.
• W2313233463 cites W2090556647 @default.
• W2313233463 cites W2103335577 @default.
• W2313233463 cites W2104599023 @default.
• W2313233463 cites W2108235071 @default.
• W2313233463 cites W2114825009 @default.
• W2313233463 cites W2116007724 @default.
• W2313233463 cites W2117184453 @default.
• W2313233463 cites W2117457995 @default.
• W2313233463 cites W2124081028 @default.
• W2313233463 cites W2129578178 @default.
• W2313233463 cites W2129882807 @default.
• W2313233463 cites W2130105783 @default.
• W2313233463 cites W2141645006 @default.
• W2313233463 cites W2147422161 @default.
• W2313233463 cites W2147921405 @default.
• W2313233463 cites W2162794208 @default.
• W2313233463 doi "https://doi.org/10.1016/j.cellsig.2016.03.015" @default.
• W2313233463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27049873" @default.
• W2313233463 hasPublicationYear "2016" @default.
• W2313233463 type Work @default.
• W2313233463 sameAs 2313233463 @default.
• W2313233463 citedByCount "24" @default.
• W2313233463 countsByYear W23132334632017 @default.
• W2313233463 countsByYear W23132334632018 @default.
• W2313233463 countsByYear W23132334632019 @default.
• W2313233463 countsByYear W23132334632020 @default.
• W2313233463 countsByYear W23132334632021 @default.
• W2313233463 countsByYear W23132334632022 @default.
• W2313233463 crossrefType "journal-article" @default.
• W2313233463 hasAuthorship W2313233463A5016933435 @default.
• W2313233463 hasAuthorship W2313233463A5027142320 @default.
• W2313233463 hasAuthorship W2313233463A5029430341 @default.
• W2313233463 hasAuthorship W2313233463A5043503859 @default.
• W2313233463 hasAuthorship W2313233463A5080191880 @default.
• W2313233463 hasAuthorship W2313233463A5084844851 @default.
• W2313233463 hasConcept C11960822 @default.
• W2313233463 hasConcept C126322002 @default.
• W2313233463 hasConcept C134018914 @default.
• W2313233463 hasConcept C139447449 @default.
• W2313233463 hasConcept C185592680 @default.
• W2313233463 hasConcept C190283241 @default.
• W2313233463 hasConcept C27740335 @default.
• W2313233463 hasConcept C2776364478 @default.
• W2313233463 hasConcept C2777391703 @default.
• W2313233463 hasConcept C2777478702 @default.
• W2313233463 hasConcept C2778367456 @default.
• W2313233463 hasConcept C2779306644 @default.
• W2313233463 hasConcept C2780124434 @default.
• W2313233463 hasConcept C502942594 @default.
• W2313233463 hasConcept C55493867 @default.
• W2313233463 hasConcept C71924100 @default.
• W2313233463 hasConcept C97029542 @default.
• W2313233463 hasConcept C98274493 @default.
• W2313233463 hasConceptScore W2313233463C11960822 @default.
• W2313233463 hasConceptScore W2313233463C126322002 @default.
• W2313233463 hasConceptScore W2313233463C134018914 @default.
• W2313233463 hasConceptScore W2313233463C139447449 @default.
• W2313233463 hasConceptScore W2313233463C185592680 @default.
• W2313233463 hasConceptScore W2313233463C190283241 @default.
• W2313233463 hasConceptScore W2313233463C27740335 @default.
• W2313233463 hasConceptScore W2313233463C2776364478 @default.
• W2313233463 hasConceptScore W2313233463C2777391703 @default.
• W2313233463 hasConceptScore W2313233463C2777478702 @default.
• W2313233463 hasConceptScore W2313233463C2778367456 @default.

• next