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- W2313236013 abstract "Forty urinary bladders from patients treated with cyclophosphamide for neoplastic disease were examined at autopsy. Ten bladders were fibrotic; three also exhibited mucosal telangiectasia. The 10 were from patients who had received the largest quantities of the drug over the longest periods. Nine of the 10 had received the drug intravenously; the tenth had received it intravenously and orally. Five had gross hematuria, but five had been asymptomatic. Urinary-bladder fibrosis occurred when total dosage exceeded 6 g/m2 of body-surface area. Adequate hydration of the patient and, when feasible, oral rather than intravenous administration of the drug may reduce urinary-bladder fibrosis associated with cyclophosphamide therapy." @default.
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- W2313236013 date "1971-02-11" @default.
- W2313236013 modified "2023-09-30" @default.
- W2313236013 title "Urinary-Bladder Fibrosis and Telangiectasia Associated with Long-Term Cyclophosphamide Therapy" @default.
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- W2313236013 doi "https://doi.org/10.1056/nejm197102112840602" @default.
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