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- W2313241745 abstract "Practical high yielding syntheses of 13-O-[(2-methoxyethoxy)methyl]-22,23-dihydroavermectin B1 aglycon (dimedectin 2-propanol, MK-324, 1) and 13-epi-O-(methoxymethyl)-22,23-dihydroavermectin B1 aglycon (L-694,554, 2), both potent flea insecticides, from ivermectin are presented. The successful selective manipulation of silyl protecting groups on ivermectin aglycon led to the facile preparation of 5,7-O-bis-silyl-22,23-dihydroavermectin B1 aglycon 7 as the key intermediate for the large scale syntheses of these compounds. Development of a dual pyridine/tertiary amine system for mesylation of the C-13α hydroxyl group of 7 and subsequent displacement with cesium propionate−propionic acid led to the successful inversion of the 13-hydroxy group." @default.
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- W2313241745 date "1997-06-13" @default.
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- W2313241745 title "Practical Syntheses of 13-<i>O</i>-[(2-Methoxyethoxy)methyl]-22,23-dihydroavermectin B<sub>1</sub> Aglycon [Dimedectin Isopropanol, MK-324] and 13-<i>epi</i>-<i>O</i>-(Methoxymethyl)-22,23-dihydroavermectin B<sub>1</sub> Aglycon [L-694,554], Flea Active Ivermectin Analogues" @default.
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- W2313241745 doi "https://doi.org/10.1021/jo970187l" @default.
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