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• W2313248518 abstract "Event Abstract Back to Event NEUROPROTECTIVE EFFECT OF GROWTH HORMONE (GH) IN HYPOXIC ORGANOTYPIC CULTURES OF CHICKEN CEREBELLUM Cinthya Córdoba-Manilla1, Clara Alba-Betancourt1, José L. Luna-Acosta1, Martha E. Carranza1, Carlos Arámburo1 and Maricela Luna1* 1 Universidad Nacional Autonoma de Mexico, Institute of Neurobiology, Dept. of Molecular and Cellular Neurobiology, Mexico Anti-apoptotic effects of growth hormone (GH) have been described in different cell types. In the central nervous system (CNS) GH has a role in neuroprotection, although the molecular mechanisms of these actions have not been fully elucidated. GH mRNA, GH and the GH receptor (GHR) are locally expressed in chicken cerebellum; this structure is particularly sensitive to damage by hypoxia-low glucose (HLG) conditions (95%N2, 5%O2, DMEM-Low Glucose, at 37°C),, leading to neuronal apoptosis and/or necrosis. In the present study, we evaluated the anti-apoptotic effect of GH in organotypic cultures of chicken cerebellum under HLG. This model has the advantage of maintaining the cytoarchitecture of normal tissue. Immunohistochemical analysis showed the co-localization of GH with NeuN in granule neurons; with Calbindin in Purkinje cells and, to a less extent, with GFAP in glial cells although the cytoarchitecture of these slices was modified under hypoxia conditions, mainly in the Purkinje layer, because these cells showed disorganization. Locally expressed GH increased under HLG conditions as compared to the control group (596.6±70.8 vs. 311.3±43.8 ng GH/mg protein, respectively, as determined by ELISA). Caspase-3 activity increased importantly in HLG treated cultures when compared to the controls under normoxia (11.6±2.1 vs 3.8± 1.0 U/ml) but was significantly reduced after addition of 1 nM GH (to 6.0 ± 0.1 U/ml). Also, GH treatment (1 nM) provoked an increase of 29.1% in the expression of Bcl2 in cultures exposed to hypoxia when compared to hypoxia alone. These results suggest that GH may act as a survival/neuroprotective factor in this ischemia model through anti-apoptotic mechanisms. Acknowledgements Supported by PAPIIT-DGAPA, UNAM 210209; CONACYT 118353 and 234456 Keywords: antiapoptotic effects of growth hormone, Caspase 3, cerebellar growth hormone, hypoxia and low glucose conditions, Ischemia, Neuroprotection, neuroprotective effects of growth hormone, organotypic cultures of chicken cerebellum Conference: NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology, Ann Arbor, United States, 13 Jul - 16 Jul, 2011. Presentation Type: Poster Topic: General neuroendocrinology Citation: Córdoba-Manilla C, Alba-Betancourt C, Luna-Acosta JL, Carranza ME, Arámburo C and Luna M (2011). NEUROPROTECTIVE EFFECT OF GROWTH HORMONE (GH) IN HYPOXIC ORGANOTYPIC CULTURES OF CHICKEN CEREBELLUM. Front. Endocrinol. Conference Abstract: NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology. doi: 10.3389/conf.fendo.2011.04.00120 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Jul 2011; Published Online: 09 Aug 2011. * Correspondence: Dr. Maricela Luna, Universidad Nacional Autonoma de Mexico, Institute of Neurobiology, Dept. of Molecular and Cellular Neurobiology, Queretaro, Queretaro, 76230, Mexico, lunam@servidor.unam.mx Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract Supplemental Data The Authors in Frontiers Cinthya Córdoba-Manilla Clara Alba-Betancourt José L Luna-Acosta Martha E Carranza Carlos Arámburo Maricela Luna Google Cinthya Córdoba-Manilla Clara Alba-Betancourt José L Luna-Acosta Martha E Carranza Carlos Arámburo Maricela Luna Google Scholar Cinthya Córdoba-Manilla Clara Alba-Betancourt José L Luna-Acosta Martha E Carranza Carlos Arámburo Maricela Luna PubMed Cinthya Córdoba-Manilla Clara Alba-Betancourt José L Luna-Acosta Martha E Carranza Carlos Arámburo Maricela Luna Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2313248518 title "NEUROPROTECTIVE EFFECT OF GROWTH HORMONE (GH) IN HYPOXIC ORGANOTYPIC CULTURES OF CHICKEN CEREBELLUM" @default.
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