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- W2313252871 endingPage "425" @default.
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- W2313252871 abstract "Statins are recommended as first-line therapy for cardiovascular disease. Unfortunately, a proportion of patients cannot tolerate these drugs because of muscle-related side-effects. This review summarizes the definition of statin-related muscle disorders, aetiological factors, and recommended management strategies.A number of consensus groups have defined and classified statin-related muscle disorders, whereas others have suggested diagnostic and management strategies. Mechanisms behind statin-related muscle toxicity have been identified. Therapeutic and clinical investigation pathways have been reviewed and algorithms defined. New drugs have become available to reduce low-density lipoprotein cholesterol levels that are not associated with causing muscle side-effects.Statin-related muscle side-effects are common. Secondary causes of muscle disease unmasked by statin therapy should be identified. Most patients can be managed by adjustment of standard treatment protocols." @default.
- W2313252871 created "2016-06-24" @default.
- W2313252871 creator A5060812655 @default.
- W2313252871 creator A5066079193 @default.
- W2313252871 date "2016-07-01" @default.
- W2313252871 modified "2023-09-26" @default.
- W2313252871 title "Statin myopathy" @default.
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- W2313252871 doi "https://doi.org/10.1097/hco.0000000000000282" @default.
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