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- W2313267512 abstract "Copyright: © 2013 Redondo M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Breast cancer is the most frequently diagnosed cancer among women. Alterations in different genes are involved in the development of this tumour [1] and alterations in crucial pathways related to proliferation and apoptosis have been used as targets for treatment [2]. Bcl-2 protein is a member of the bcl-2 family that regulates apoptosis. The bcl-2 gene encodes a MR 26000 protein that is mainly localized in the mitochondrial membrane and, to a lesser extent, in the nuclear membrane and the endoplasmic reticulum. Its implication in carcinogenesis and progression makes this gene worthy of investigation. Its tumourigenic potential has been demonstrated: bcl-2 protein blocks apoptosis and cooperates with c-myc in cell transformation [3]. In addition, in the MCF-7 breast cancer cell line the overexpression of bcl-2 enhances both tumourigenicity and metastatic potential [4]. However, in many solid organ tumours, including breast cancer, bcl2 expression, paradoxically, is associated with favourable prognostic features and good outcome [5,6]. Interestingly, the expression of bcl2 is higher in screen-detected cancers than in symptomatic cancers [7] and, in a recent report, bcl-2 expression was shown to be lower in the stroma of precancerous fibroadenoma lesions than in those of non-cancerous lesions [8]. In their metaanalyses, Dawson et al. [6] supported the prognostic role of bcl-2 in breast cancer, as assessed by immunochemistry, and showed that this effect is independent of other variables." @default.
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- W2313267512 date "2013-01-01" @default.
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- W2313267512 title "Bcl-2, an Antiapoptotic Gene Indicator of Good Prognosis in Breast Cancer: The Paradox" @default.
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- W2313267512 doi "https://doi.org/10.4172/2157-2518.1000134" @default.
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