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- W2313272216 abstract "Background Evidence suggests rheumatoid arthritis (RA) confers an increased risk of psychological morbidity, particularly anxiety and depression, which may affect the subsequent management and treatment adherence.[1][1],[2][2] Few studies have studied psychological factors over time in RA patients.[3][3]Objectives We aimed to evaluate the prevalence of anxiety and depression in RA patients following rituximab treatment initiation and prolongation.Methods Biologics-naive RA patients were followed up for 27 months after commencing and continuing rituximab therapy (1, 2, 3 standard courses). Anxiety and depression, and health-related quality of life (HRQoL) were assessed at baseline, 3, 15 and 27 months using the Hospital Anxiety and Depression Scale (HADS) and the Short Form (SF-36 v.1) Health Survey questionnaire, respectively.Results 86 patients [mean (SD) age 49.2 (9.3) years, 76 women; median (IQR) DAS28 5.64 (3.92–8.42); median (IQR) HAQ 1.85 (1.0–3.5)] were recruited. Median anxiety and depression scores decreased significantly between baseline and 3 months (p<0.001) and remained decreased over the 27-month period. The prevalence of depression cases decreased twice from baseline to 27 months (66.3% to 30.0%), as did the prevalence of anxiety (79.1% to 40.0%). Patients reported poor baseline HRQoL. SF-36 v.1 domain scores substantially raised after 15 months.![Figure][4] Conclusions Anxiety and depression levels decrease significantly following commencement and continuity of rituximab. B cell-directed therapy for patients with RA helps achieve remission of both anxiety and depression, and improves health-related quality of life.References 1. McWilliams LA, Goodvin RD, Cox BJ. Depression and anxiety associated with three pain conditions: results from a nationally representative sample. Pain 2004;111:77–83.2. Garcia-Cebrian A, Gandhi P, Demyttenaere K et al. The association of depression and painful physical symptoms: a review of the European literature. Eur Psychiatry 2006;21:379–388.3. Overman CL, Bossema ER, van Middendorp H et al. The prospective association between psychological distress and disease activity in rheumatoid arthritis: a multilevel regression analysis. Ann Rheum Dis 2012;71:192–197.Disclosure of Interest : None Declared [1]: #p-6 [2]: #p-7 [3]: #p-8 [4]: pending:yes" @default.
- W2313272216 created "2016-06-24" @default.
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- W2313272216 date "2013-06-01" @default.
- W2313272216 modified "2023-09-27" @default.
- W2313272216 title "FRI0239 Decreased prevalence of anxiety and depression in rheumatoid arthritis patients following b cell-targeted biologic therapy" @default.
- W2313272216 doi "https://doi.org/10.1136/annrheumdis-2013-eular.1366" @default.
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