FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313302556> ?p ?o ?g. }

• W2313302556 endingPage "23" @default.
• W2313302556 startingPage "14" @default.
• W2313302556 abstract "Histone deacetylase inhibitors (HDACi) induce acetylation of histone and non-histone proteins, and modulate the acetylation of proteins involved in DNA double-strand break (DSB) repair. Non-homologous end-joining (NHEJ) is one of the main pathways for repairing DSBs. Decreased NHEJ activity has been reported with HDACi treatment. However, mechanisms through which these effects are regulated in the context of chromatin are unclear. We show that pan-HDACi, trichostatin A (TSA), causes differential acetylation of DNA repair factors Ku70/Ku80 and poly ADP-ribose polymerase-1 (PARP1), and impairs NHEJ. Repair effects are reversed by treatments with p300/CBP inhibitor C646, with significantly decreased acetylation of PARP1. In keeping with these findings, TSA treatment significantly increases PARP1 binding to DSBs in chromatin. Notably, AML patients treated with HDACi entinostat (MS275) in vivo also show increased formation of poly ADP-ribose (PAR) that co-localizes with DSBs. Further, we demonstrate that PARP1 bound to chromatin increases with duration of TSA exposure, resembling PARP trapping. Knockdown of PARP1 inhibits trapping and mitigates HDACi effects on NHEJ. Finally, combination of HDACi with potent PARP inhibitor talazoparib (BMN673) shows a dose-dependent increase in PARP trapping, which correlates with increased apoptosis. These results provide a mechanism through which HDACi inhibits deacetylation and increases binding of PARP1 to DSBs, leading to decreased NHEJ and cytotoxicity of leukemia cells." @default.
• W2313302556 created "2016-06-24" @default.
• W2313302556 creator A5008802134 @default.
• W2313302556 creator A5018061374 @default.
• W2313302556 creator A5022779808 @default.
• W2313302556 creator A5040462753 @default.
• W2313302556 creator A5045398774 @default.
• W2313302556 creator A5046719320 @default.
• W2313302556 creator A5067344353 @default.
• W2313302556 creator A5068348789 @default.
• W2313302556 date "2016-06-01" @default.
• W2313302556 modified "2023-10-17" @default.
• W2313302556 title "Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin" @default.
• W2313302556 cites W143763378 @default.
• W2313302556 cites W1599317164 @default.
• W2313302556 cites W1822429854 @default.
• W2313302556 cites W1828848048 @default.
• W2313302556 cites W1967018540 @default.
• W2313302556 cites W1969106931 @default.
• W2313302556 cites W1970225082 @default.
• W2313302556 cites W1974090542 @default.
• W2313302556 cites W1977342842 @default.
• W2313302556 cites W1979299166 @default.
• W2313302556 cites W1980947442 @default.
• W2313302556 cites W1985775217 @default.
• W2313302556 cites W1990636453 @default.
• W2313302556 cites W1990801507 @default.
• W2313302556 cites W1993510744 @default.
• W2313302556 cites W1993916591 @default.
• W2313302556 cites W1995920076 @default.
• W2313302556 cites W1997154923 @default.
• W2313302556 cites W2004980848 @default.
• W2313302556 cites W2007321086 @default.
• W2313302556 cites W2008650297 @default.
• W2313302556 cites W2015414930 @default.
• W2313302556 cites W2022811243 @default.
• W2313302556 cites W2026222185 @default.
• W2313302556 cites W2032365508 @default.
• W2313302556 cites W2033858594 @default.
• W2313302556 cites W2039655187 @default.
• W2313302556 cites W2040771704 @default.
• W2313302556 cites W2044570206 @default.
• W2313302556 cites W2046916766 @default.
• W2313302556 cites W2050164541 @default.
• W2313302556 cites W2053844006 @default.
• W2313302556 cites W2054407912 @default.
• W2313302556 cites W2055530920 @default.
• W2313302556 cites W2061020520 @default.
• W2313302556 cites W2063299963 @default.
• W2313302556 cites W2066204526 @default.
• W2313302556 cites W2068668324 @default.
• W2313302556 cites W2071115015 @default.
• W2313302556 cites W2076082538 @default.
• W2313302556 cites W2077489154 @default.
• W2313302556 cites W2082618949 @default.
• W2313302556 cites W2084291773 @default.
• W2313302556 cites W2094950317 @default.
• W2313302556 cites W2098536205 @default.
• W2313302556 cites W2098737737 @default.
• W2313302556 cites W2107277218 @default.
• W2313302556 cites W2107325904 @default.
• W2313302556 cites W2110804935 @default.
• W2313302556 cites W2116478273 @default.
• W2313302556 cites W2128916321 @default.
• W2313302556 cites W2147413224 @default.
• W2313302556 cites W2156712995 @default.
• W2313302556 cites W2171028011 @default.
• W2313302556 cites W2192080449 @default.
• W2313302556 cites W2406549746 @default.
• W2313302556 doi "https://doi.org/10.1016/j.leukres.2016.03.007" @default.
• W2313302556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5007632" @default.
• W2313302556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27064363" @default.
• W2313302556 hasPublicationYear "2016" @default.
• W2313302556 type Work @default.
• W2313302556 sameAs 2313302556 @default.
• W2313302556 citedByCount "60" @default.
• W2313302556 countsByYear W23133025562017 @default.
• W2313302556 countsByYear W23133025562018 @default.
• W2313302556 countsByYear W23133025562019 @default.
• W2313302556 countsByYear W23133025562020 @default.
• W2313302556 countsByYear W23133025562021 @default.
• W2313302556 countsByYear W23133025562022 @default.
• W2313302556 countsByYear W23133025562023 @default.
• W2313302556 crossrefType "journal-article" @default.
• W2313302556 hasAuthorship W2313302556A5008802134 @default.
• W2313302556 hasAuthorship W2313302556A5018061374 @default.
• W2313302556 hasAuthorship W2313302556A5022779808 @default.
• W2313302556 hasAuthorship W2313302556A5040462753 @default.
• W2313302556 hasAuthorship W2313302556A5045398774 @default.
• W2313302556 hasAuthorship W2313302556A5046719320 @default.
• W2313302556 hasAuthorship W2313302556A5067344353 @default.
• W2313302556 hasAuthorship W2313302556A5068348789 @default.
• W2313302556 hasBestOaLocation W23133025562 @default.
• W2313302556 hasConcept C104317684 @default.
• W2313302556 hasConcept C119157956 @default.
• W2313302556 hasConcept C134935766 @default.
• W2313302556 hasConcept C143425029 @default.
• W2313302556 hasConcept C153911025 @default.

• next