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• W2313303088 abstract "Active pharmaceutical ingredients are often synthesized by multiple reactions involving organometallic catalysts, and it is necessary for substrates to pass through several reaction and separation steps during processing. Flow chemistry is an attractive solution for multistep synthesis, but between reactions, streams require workup and purification using techniques such as liquid–liquid extraction, gas–liquid separation, distillation, and others. Organic solvent nanofiltration (OSN) is an emerging technology for performing membrane separation/purification processes in organic solvents which offers major advantages for performing catalyst separation in a continuous process without phase transition or biphasic operations. The main challenges faced by in situ continuous separation of catalysts by OSN are the compatibility of membranes with the reaction conditions (high temperature, aggressive solvents, and often high concentrations of acid/base). This work demonstrates, for the first time, a one-pot, long-term continuous Heck coupling reaction performed in DMF at 80 °C and organic base concentrations >0.9 mol·L–1, where the Pd catalyst is retained by a polymeric OSN membrane. The process achieved stable performance for more than 1000 h at conversion rates higher than 85%. The average product contamination in the continuous process integrated with membrane separation was 20 times lower than in a simple batch process utilising the same catalyst loading." @default.
• W2313303088 created "2016-06-24" @default.
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• W2313303088 date "2013-06-26" @default.
• W2313303088 modified "2023-10-14" @default.
• W2313303088 title "On the Potential of Organic Solvent Nanofiltration in Continuous Heck Coupling Reactions" @default.
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• W2313303088 doi "https://doi.org/10.1021/op400073p" @default.
• W2313303088 hasPublicationYear "2013" @default.
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