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- W2313303868 abstract "We investigated the dynamic aspects of circulatory interleukin (IL)-18 in patients who underwent a hepatectomy. In patients with hepatic failure after surgery, plasma concentrations of IL-6 and IL-10 increased in the early phase; however, the plasma concentrations of IL-18 increased in the later phase after 1 week. Interestingly, the increase in the plasma IL-18 concentration was correlated with that in serum bilirubin levels in hepatectomized patients. Hence, the decrease in the hepatic metabolism of IL-18 may cause the plasma accumulation of IL-18. This mechanism was confirmed using rat experiments. Intravenously administrated human IL-18 was excreted in bile. Furthermore, the plasma clearance of human IL-18 was prolonged in bile-duct-ligated rats. These results suggest that IL-18 is metabolized in the liver and excreted in bile, and an increase in plasma IL-18 in patients with hepatic failure reflects the decreased metabolism in the liver." @default.
- W2313303868 created "2016-06-24" @default.
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- W2313303868 date "2002-03-01" @default.
- W2313303868 modified "2023-09-26" @default.
- W2313303868 title "Increased Concentrations of Plasma Interleukin-18 in Patients With Hepatic Failure 1 Week After Surgery" @default.
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- W2313303868 doi "https://doi.org/10.1097/00002371-200203001-00013" @default.
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