FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313306567> ?p ?o ?g. }

• W2313306567 endingPage "1571" @default.
• W2313306567 startingPage "1565" @default.
• W2313306567 abstract "Benzene oxide (BO) reacts with cysteinyl residues in hemoglobin (Hb) and albumin (Alb) to form protein adducts (BO-Hb and BO-Alb), which are presumed to be specific biomarkers of exposure to benzene. We analyzed BO-Hb in 43 exposed workers and 42 unexposed controls, and BO-Alb in a subsample consisting of 19 workers and 19 controls from Shanghai, China, as part of a larger cross-sectional study of benzene biomarkers. The adducts were analyzed by gas chromatography-mass spectrometry following reaction of the protein with trifluoroacetic anhydride and methanesulfonic acid. When subjects were divided into controls (n = 42) and workers exposed to < or =31 (n = 21) and >31 p.p.m. (n = 22) benzene, median BO-Hb levels were 32.0, 46.7 and 129 pmol/g globin, respectively (correlation with exposure: Spearman r = 0.67, P < 0.0001). To our knowledge, these results represent the first observation in humans that BO-Hb levels are significantly correlated with benzene exposure. Median BO-Alb levels in these 3 groups were 103 (n = 19), 351 (n = 7) and 2010 (n = 12) pmol/g Alb, respectively, also reflecting a significant correlation with exposure (Spearman r = 0.90, P < 0.0001). The blood dose of BO predicted from both Hb and Alb adducts was very similar. These results clearly affirm the use of both Hb and Alb adducts of BO as biomarkers of exposure to high levels of benzene. As part of our investigation of the background levels of BO-Hb and BO-Alb found in unexposed persons, we analyzed recombinant human Hb and Alb for BO adducts. Significant levels of both BO-Hb (19.7 pmol/g) and BO-Alb (41.9 pmol/g) were detected, suggesting that portions of the observed background adducts reflect an artifact of the assay, while other portions are indicative of either unknown exposures or endogenous production of adducts." @default.
• W2313306567 created "2016-06-24" @default.
• W2313306567 creator A5010924875 @default.
• W2313306567 creator A5027078971 @default.
• W2313306567 creator A5029439241 @default.
• W2313306567 creator A5041461230 @default.
• W2313306567 creator A5045459390 @default.
• W2313306567 creator A5057653053 @default.
• W2313306567 creator A5067056115 @default.
• W2313306567 creator A5068037678 @default.
• W2313306567 creator A5075251834 @default.
• W2313306567 creator A5077743963 @default.
• W2313306567 creator A5091859226 @default.
• W2313306567 date "1998-09-01" @default.
• W2313306567 modified "2023-10-12" @default.
• W2313306567 title "Hemoglobin and albumin adducts of benzene oxide among workers exposed to high levels of benzene" @default.
• W2313306567 cites W1512203084 @default.
• W2313306567 cites W152806176 @default.
• W2313306567 cites W1967388340 @default.
• W2313306567 cites W1972719789 @default.
• W2313306567 cites W1980787460 @default.
• W2313306567 cites W1991499205 @default.
• W2313306567 cites W1993724595 @default.
• W2313306567 cites W1993757992 @default.
• W2313306567 cites W1996034008 @default.
• W2313306567 cites W1998880088 @default.
• W2313306567 cites W2005679749 @default.
• W2313306567 cites W2012547337 @default.
• W2313306567 cites W2024465058 @default.
• W2313306567 cites W2027312449 @default.
• W2313306567 cites W2040223458 @default.
• W2313306567 cites W2042057331 @default.
• W2313306567 cites W2054143023 @default.
• W2313306567 cites W2054859731 @default.
• W2313306567 cites W2061582161 @default.
• W2313306567 cites W2066856430 @default.
• W2313306567 cites W2076566189 @default.
• W2313306567 cites W2095003207 @default.
• W2313306567 cites W2120775510 @default.
• W2313306567 cites W2128279248 @default.
• W2313306567 cites W2142359899 @default.
• W2313306567 cites W2157382699 @default.
• W2313306567 cites W2161838380 @default.
• W2313306567 cites W2315241879 @default.
• W2313306567 cites W2525772635 @default.
• W2313306567 cites W2797431976 @default.
• W2313306567 doi "https://doi.org/10.1093/carcin/19.9.1565" @default.
• W2313306567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9771926" @default.
• W2313306567 hasPublicationYear "1998" @default.
• W2313306567 type Work @default.
• W2313306567 sameAs 2313306567 @default.
• W2313306567 citedByCount "63" @default.
• W2313306567 countsByYear W23133065672012 @default.
• W2313306567 countsByYear W23133065672013 @default.
• W2313306567 countsByYear W23133065672015 @default.
• W2313306567 countsByYear W23133065672018 @default.
• W2313306567 countsByYear W23133065672019 @default.
• W2313306567 countsByYear W23133065672021 @default.
• W2313306567 countsByYear W23133065672022 @default.
• W2313306567 countsByYear W23133065672023 @default.
• W2313306567 crossrefType "journal-article" @default.
• W2313306567 hasAuthorship W2313306567A5010924875 @default.
• W2313306567 hasAuthorship W2313306567A5027078971 @default.
• W2313306567 hasAuthorship W2313306567A5029439241 @default.
• W2313306567 hasAuthorship W2313306567A5041461230 @default.
• W2313306567 hasAuthorship W2313306567A5045459390 @default.
• W2313306567 hasAuthorship W2313306567A5057653053 @default.
• W2313306567 hasAuthorship W2313306567A5067056115 @default.
• W2313306567 hasAuthorship W2313306567A5068037678 @default.
• W2313306567 hasAuthorship W2313306567A5075251834 @default.
• W2313306567 hasAuthorship W2313306567A5077743963 @default.
• W2313306567 hasAuthorship W2313306567A5091859226 @default.
• W2313306567 hasConcept C108204754 @default.
• W2313306567 hasConcept C126322002 @default.
• W2313306567 hasConcept C134018914 @default.
• W2313306567 hasConcept C178790620 @default.
• W2313306567 hasConcept C185592680 @default.
• W2313306567 hasConcept C2776125364 @default.
• W2313306567 hasConcept C2777691172 @default.
• W2313306567 hasConcept C2778917026 @default.
• W2313306567 hasConcept C55493867 @default.
• W2313306567 hasConcept C71924100 @default.
• W2313306567 hasConceptScore W2313306567C108204754 @default.
• W2313306567 hasConceptScore W2313306567C126322002 @default.
• W2313306567 hasConceptScore W2313306567C134018914 @default.
• W2313306567 hasConceptScore W2313306567C178790620 @default.
• W2313306567 hasConceptScore W2313306567C185592680 @default.
• W2313306567 hasConceptScore W2313306567C2776125364 @default.
• W2313306567 hasConceptScore W2313306567C2777691172 @default.
• W2313306567 hasConceptScore W2313306567C2778917026 @default.
• W2313306567 hasConceptScore W2313306567C55493867 @default.
• W2313306567 hasConceptScore W2313306567C71924100 @default.
• W2313306567 hasIssue "9" @default.
• W2313306567 hasLocation W23133065671 @default.
• W2313306567 hasLocation W23133065672 @default.
• W2313306567 hasOpenAccess W2313306567 @default.
• W2313306567 hasPrimaryLocation W23133065671 @default.
• W2313306567 hasRelatedWork W1912959589 @default.

• next