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- W2313307619 startingPage "68" @default.
- W2313307619 abstract "The evaluation of toxicological effects of nanoparticles (NPs) is increasingly important due to their growing occupational use and presence as compounds in consumer products. Recent researches have demonstrated that long-term exposure to air particulate matter can induce cardiovascular events, but whether cardiovascular disease, such as cardiac damage, is induced by NP exposure and its toxic mechanisms is rarely evaluated. In the present study, when mice were continuously exposed to TiO2 NPs at 2.5, 5 or 10 mg/kg BW by intragastric administration for 90 days, obvious histopathological changes, and great alterations of NF-κB and its inhibitor I-κB, as well as TNF-α, IL-1β, IL-6 and IFN-α expression were induced. The NPs significantly decreased Ca2+-ATPase, Ca2+/Mg2+-ATPase and Na+/K+-ATPase activities and enhanced NCX-1 content. The NPs also considerably increased CAMK II and α1/β1-AR expression and up-regulated p-PKCε and p-ERK1/2 in a dose-dependent manner in the mouse heart. These data suggest that low-dose and long-term exposure to TiO2 NPs may cause cardiac damage such as cardiac fragmentation or disordered myocardial fibre arrangement, tissue necrosis, myocardial haemorrhage, swelling or cardiomyocyte hypertrophy, and the inflammatory response was potentially mediated by NF-κB activation via the PKCε or ERK1/2 signalling cascades in mice." @default.
- W2313307619 created "2016-06-24" @default.
- W2313307619 creator A5014888653 @default.
- W2313307619 creator A5032117360 @default.
- W2313307619 creator A5032984193 @default.
- W2313307619 date "2016-08-01" @default.
- W2313307619 modified "2023-10-18" @default.
- W2313307619 title "Cardiac inflammation involving in PKCε or ERK1/2-activated NF-κB signalling pathway in mice following exposure to titanium dioxide nanoparticles" @default.
- W2313307619 cites W1533160334 @default.
- W2313307619 cites W1538520686 @default.
- W2313307619 cites W1566255459 @default.
- W2313307619 cites W1810029706 @default.
- W2313307619 cites W1842845667 @default.
- W2313307619 cites W1846979127 @default.
- W2313307619 cites W1964096311 @default.
- W2313307619 cites W1964829247 @default.
- W2313307619 cites W1980754997 @default.
- W2313307619 cites W1987720329 @default.
- W2313307619 cites W1988585626 @default.
- W2313307619 cites W1988666024 @default.
- W2313307619 cites W1990542291 @default.
- W2313307619 cites W1992290425 @default.
- W2313307619 cites W1994092760 @default.
- W2313307619 cites W1994539985 @default.
- W2313307619 cites W2001057967 @default.
- W2313307619 cites W2002003950 @default.
- W2313307619 cites W2005153037 @default.
- W2313307619 cites W2005535029 @default.
- W2313307619 cites W2008245558 @default.
- W2313307619 cites W2008939735 @default.
- W2313307619 cites W2009506954 @default.
- W2313307619 cites W2011397271 @default.
- W2313307619 cites W2011879443 @default.
- W2313307619 cites W2013395601 @default.
- W2313307619 cites W2022786065 @default.
- W2313307619 cites W2023592455 @default.
- W2313307619 cites W2026094062 @default.
- W2313307619 cites W2028889452 @default.
- W2313307619 cites W2029382346 @default.
- W2313307619 cites W2033041008 @default.
- W2313307619 cites W2033546645 @default.
- W2313307619 cites W2038343834 @default.
- W2313307619 cites W2045282097 @default.
- W2313307619 cites W2045580583 @default.
- W2313307619 cites W2046266035 @default.
- W2313307619 cites W2048553024 @default.
- W2313307619 cites W2049537875 @default.
- W2313307619 cites W2049711416 @default.
- W2313307619 cites W2050659068 @default.
- W2313307619 cites W2051105080 @default.
- W2313307619 cites W2051414004 @default.
- W2313307619 cites W2053761680 @default.
- W2313307619 cites W2058289508 @default.
- W2313307619 cites W2060555694 @default.
- W2313307619 cites W2060857908 @default.
- W2313307619 cites W2060873921 @default.
- W2313307619 cites W2062633171 @default.
- W2313307619 cites W2064496626 @default.
- W2313307619 cites W2064727565 @default.
- W2313307619 cites W2069386896 @default.
- W2313307619 cites W2071800732 @default.
- W2313307619 cites W2072929449 @default.
- W2313307619 cites W2079047912 @default.
- W2313307619 cites W2081665546 @default.
- W2313307619 cites W2082849114 @default.
- W2313307619 cites W2084330407 @default.
- W2313307619 cites W2087812848 @default.
- W2313307619 cites W2091991738 @default.
- W2313307619 cites W2100026340 @default.
- W2313307619 cites W2102266441 @default.
- W2313307619 cites W2107704792 @default.
- W2313307619 cites W2112162648 @default.
- W2313307619 cites W2113979526 @default.
- W2313307619 cites W2114904404 @default.
- W2313307619 cites W2120071301 @default.
- W2313307619 cites W2127025705 @default.
- W2313307619 cites W2127259475 @default.
- W2313307619 cites W2135308161 @default.
- W2313307619 cites W2140427091 @default.
- W2313307619 cites W2141524160 @default.
- W2313307619 cites W2142609785 @default.
- W2313307619 cites W2144346980 @default.
- W2313307619 cites W2147602331 @default.
- W2313307619 cites W2150210392 @default.
- W2313307619 cites W2150751323 @default.
- W2313307619 cites W2155366909 @default.
- W2313307619 cites W2158034990 @default.
- W2313307619 cites W2158867171 @default.
- W2313307619 cites W2162665617 @default.
- W2313307619 cites W2163828032 @default.
- W2313307619 cites W2168058345 @default.
- W2313307619 cites W2172243272 @default.
- W2313307619 cites W2186114039 @default.
- W2313307619 cites W2311842275 @default.
- W2313307619 cites W2323831772 @default.
- W2313307619 cites W2325928137 @default.
- W2313307619 cites W2342067684 @default.
- W2313307619 cites W2603988640 @default.