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• W2313324101 endingPage "5886" @default.
• W2313324101 startingPage "5877" @default.
• W2313324101 abstract "In the present study, 1H HRMAS NMR spectroscopy was used to assess the changes in the intracellular metabolic profile of MG-63 human osteosarcoma (OS) cells induced by the chemotherapy agent cisplatin (CDDP) at different times of exposure. Multivariate analysis was applied to the cells spectra, enabling consistent variation patterns to be detected and drug-specific metabolic effects to be identified. Statistical recoupling of variables (SRV) analysis and spectral integration enabled the most relevant spectral changes to be evaluated, revealing significant time-dependent alterations in lipids, choline-containing compounds, some amino acids, polyalcohols, and nitrogenated bases. The metabolic relevance of these compounds in the response of MG-63 cells to CDDP treatment is discussed." @default.
• W2313324101 created "2016-06-24" @default.
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• W2313324101 date "2010-09-27" @default.
• W2313324101 modified "2023-09-26" @default.
• W2313324101 title "Nuclear Magnetic Resonance (NMR) Study of the Effect of Cisplatin on the Metabolic Profile of MG-63 Osteosarcoma Cells" @default.
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• W2313324101 doi "https://doi.org/10.1021/pr100635n" @default.
• W2313324101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20815413" @default.
• W2313324101 hasPublicationYear "2010" @default.
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