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- W2313336504 abstract "In the quality test of five brands of plane tablets containing 400 mg of sulfamethoxazole (SMX) and 80mg of hoprim (TMP), their dissolution, weight variation, content uniformity, disintegration and hardness were studied.The complementary tristimulus colorimetry (CTS method) which has the advantage of simultaneous determination of two or three components, was applied to the analysis of SMX and TMP of dissolution test.In the CTS method, three wavelengths are settled on the absorption spectra in order to represent the character of components and the absorbances of pure compounds and their mixtures are measured at these wavelengths.In the dissolution test using the 1st fluid of JP XI of disintegration test by paddle method, 100 rpm was used.Their weight variation was 0.48 to 1.07%, and disintegration time less than 6.72 min, which meet the JP XI requirements.The hardness of these studied tablets were found between 9.9 and 14.9 kg/cm2.The content of SMX were 390.8 to 408.2 mg, and TMP 79.7 to 81.8 mg, by USP XXI requirement. Our results indicated that the determination and dissolution patterns of five SMX and TMP tablets were different, and the CTS method is useful in dissolution test of tablet containing two or three components." @default.
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- W2313336504 date "1992-01-01" @default.
- W2313336504 modified "2023-09-24" @default.
- W2313336504 title "Dissolution Characteristics of Tablet Containing Sulfamethoxazole and Trimethoprim on the Market." @default.
- W2313336504 doi "https://doi.org/10.5649/jjphcs1975.18.139" @default.
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