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- W2313358103 abstract "The administration of amphotericin B (AmB) is often limited by the development of nephrotoxicity. In a pilot crossover trial, aqueous AmB followed by a new preparation of a mixture of AmB with 20% intralipid (AmB-IL) was administered to 10 immunocompromised patients for systemic fungal infections caused by Candida species. Mean total dose and duration of therapy with AmB-IL exceeded that of aqueous AmB (649±165 mg versus 394±105 mg, P=0.061 and 13.2±2.5 days versus 9±2.1 days, P=0.31). However, mean creatinine clearance of the patients rose during AmB-IL therapy by 10.7±7.7 mL/min (P=0.03). AmB-IL warrants further investigation to assess its stability and efficacy for treating serious fungal infections." @default.
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- W2313358103 date "1997-01-01" @default.
- W2313358103 modified "2023-09-25" @default.
- W2313358103 title "Reduction in the Nephrotoxicity of Amphotericin B when Administered in 20% Intralipid" @default.
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- W2313358103 doi "https://doi.org/10.1155/1997/827297" @default.
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