FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313360149> ?p ?o ?g. }

• W2313360149 endingPage "183" @default.
• W2313360149 startingPage "176" @default.
• W2313360149 abstract "The CCN proteins are key signaling and regulatory molecules involved in many biological functions and contribute to malignant and non-malignant lung diseases. Despite the high morbidity and mortality of the lung respiratory infectious diseases, there is very little data related to the expression of the CCNs during infection. We investigated in mice the pulmonary mRNA expression levels of five CCNs (1 to 5) in response to influenza A virus (IAV) and bacterial agents (Nontypeable Haemophilus influenzae (NTHi), lipopolysaccharide (LPS) and lipoteichoic acid (LTA)). IAV, NTHi, LPS or LTA were instilled intranasally into mice. Mice were also exposed for 4 days or 8 weeks to cigarette smoke alone or prior infection to IAV in order to determine if CS modifies the CCN response to a viral infection. All challenges induced a robust inflammation. The mRNA expression of CCN1, CCN2 and CCN3 was decreased after short exposure to CS whereas prolonged exposure altered the expression of CCN1, CCN3 and CCN4. Influenza A virus infection increased CCN1, 2, 4 and 5 mRNA levels but expression of CCN3 was significantly decreased. Acute CS exposure prior infection had little effect on the expression of CCN genes but prolonged exposure abolished the IAV-dependent induction. Treatment with LPS or LTA and infection with NTHi revealed that both Gram-positive and Gram–negative bacteria rapidly modulate the expression of the CCN genes. Our findings reveal that several triggers of lung inflammation influence differently the CCN genes. CCN3 deserves special attention since its mRNA expression is decreased by all the triggers studied." @default.
• W2313360149 created "2016-06-24" @default.
• W2313360149 creator A5005562488 @default.
• W2313360149 creator A5010209130 @default.
• W2313360149 creator A5037124332 @default.
• W2313360149 creator A5061309096 @default.
• W2313360149 creator A5064037216 @default.
• W2313360149 creator A5073374209 @default.
• W2313360149 creator A5080045201 @default.
• W2313360149 creator A5080289697 @default.
• W2313360149 creator A5086335311 @default.
• W2313360149 date "2016-07-01" @default.
• W2313360149 modified "2023-09-26" @default.
• W2313360149 title "Altered expression of the CCN genes in the lungs of mice in response to cigarette smoke exposure and viral and bacterial infections" @default.
• W2313360149 cites W1578805809 @default.
• W2313360149 cites W1785914948 @default.
• W2313360149 cites W1952903895 @default.
• W2313360149 cites W1964244580 @default.
• W2313360149 cites W1966847830 @default.
• W2313360149 cites W1971328692 @default.
• W2313360149 cites W1979122784 @default.
• W2313360149 cites W1980397078 @default.
• W2313360149 cites W1984841510 @default.
• W2313360149 cites W2001152234 @default.
• W2313360149 cites W2004588239 @default.
• W2313360149 cites W2017736914 @default.
• W2313360149 cites W2023181289 @default.
• W2313360149 cites W2032559539 @default.
• W2313360149 cites W2034423141 @default.
• W2313360149 cites W2036899152 @default.
• W2313360149 cites W2042245784 @default.
• W2313360149 cites W2053375738 @default.
• W2313360149 cites W2053865773 @default.
• W2313360149 cites W2057704272 @default.
• W2313360149 cites W2060075310 @default.
• W2313360149 cites W2060163874 @default.
• W2313360149 cites W2068119771 @default.
• W2313360149 cites W2077875665 @default.
• W2313360149 cites W2079720344 @default.
• W2313360149 cites W2085292382 @default.
• W2313360149 cites W2099063127 @default.
• W2313360149 cites W2103071509 @default.
• W2313360149 cites W2110613845 @default.
• W2313360149 cites W2112067387 @default.
• W2313360149 cites W2131935567 @default.
• W2313360149 cites W2138125843 @default.
• W2313360149 cites W2141249815 @default.
• W2313360149 cites W2143670954 @default.
• W2313360149 cites W2163131422 @default.
• W2313360149 cites W2172161720 @default.
• W2313360149 cites W2322031379 @default.
• W2313360149 doi "https://doi.org/10.1016/j.gene.2016.04.022" @default.
• W2313360149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27080955" @default.
• W2313360149 hasPublicationYear "2016" @default.
• W2313360149 type Work @default.
• W2313360149 sameAs 2313360149 @default.
• W2313360149 citedByCount "10" @default.
• W2313360149 countsByYear W23133601492016 @default.
• W2313360149 countsByYear W23133601492017 @default.
• W2313360149 countsByYear W23133601492018 @default.
• W2313360149 countsByYear W23133601492019 @default.
• W2313360149 countsByYear W23133601492020 @default.
• W2313360149 countsByYear W23133601492023 @default.
• W2313360149 crossrefType "journal-article" @default.
• W2313360149 hasAuthorship W2313360149A5005562488 @default.
• W2313360149 hasAuthorship W2313360149A5010209130 @default.
• W2313360149 hasAuthorship W2313360149A5037124332 @default.
• W2313360149 hasAuthorship W2313360149A5061309096 @default.
• W2313360149 hasAuthorship W2313360149A5064037216 @default.
• W2313360149 hasAuthorship W2313360149A5073374209 @default.
• W2313360149 hasAuthorship W2313360149A5080045201 @default.
• W2313360149 hasAuthorship W2313360149A5080289697 @default.
• W2313360149 hasAuthorship W2313360149A5086335311 @default.
• W2313360149 hasConcept C104317684 @default.
• W2313360149 hasConcept C126322002 @default.
• W2313360149 hasConcept C150194340 @default.
• W2313360149 hasConcept C203014093 @default.
• W2313360149 hasConcept C2522874641 @default.
• W2313360149 hasConcept C2776914184 @default.
• W2313360149 hasConcept C2777546802 @default.
• W2313360149 hasConcept C2777714996 @default.
• W2313360149 hasConcept C2778754761 @default.
• W2313360149 hasConcept C2779489039 @default.
• W2313360149 hasConcept C523546767 @default.
• W2313360149 hasConcept C54355233 @default.
• W2313360149 hasConcept C55493867 @default.
• W2313360149 hasConcept C6977687 @default.
• W2313360149 hasConcept C71924100 @default.
• W2313360149 hasConcept C86803240 @default.
• W2313360149 hasConcept C89423630 @default.
• W2313360149 hasConceptScore W2313360149C104317684 @default.
• W2313360149 hasConceptScore W2313360149C126322002 @default.
• W2313360149 hasConceptScore W2313360149C150194340 @default.
• W2313360149 hasConceptScore W2313360149C203014093 @default.
• W2313360149 hasConceptScore W2313360149C2522874641 @default.
• W2313360149 hasConceptScore W2313360149C2776914184 @default.
• W2313360149 hasConceptScore W2313360149C2777546802 @default.
• W2313360149 hasConceptScore W2313360149C2777714996 @default.

• next