Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313360771> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2313360771 endingPage "2063" @default.
- W2313360771 startingPage "2055" @default.
- W2313360771 abstract "The regeneration characteristics and biological activities of mitomycin C-dextran conjugate (MMC-D) were investigated in comparison with those of free mitomycin C (MMC), and the following results were obtained. (1) MMC is coupled at the 1a-nitrogen position via an amide linkage to a carboxyl group of ε-aminocaproic acid (6-aminohexanoic acid) which was introduced onto dextran as a spacer. (2) MMC-D was stabler than MMC against acid-catalyzed and metabolic degradation. (3) MMC was liberated from MMC-D with a half-life of about 24 h under physiological conditions (pH 7.4, 37°C) and more rapidly at higher pH. (4) Liver homogenate did not accelerate the liberation of MMC from MMC-D. (5) Antimicrobial activity of MMC-D against Escherichia coli B was less than one-eighteenth of that of MMC. (6) MMC-D showed about one-tenth of the antitumor activity of MMC in vitro in contact with L1210 leukemia cells, but showed almost equal efficiency in the i. p.-i. p. system in vivo, suggesting that MMC-D exhibited activity after being regenerated to the parent drug in the body." @default.
- W2313360771 created "2016-06-24" @default.
- W2313360771 creator A5005177820 @default.
- W2313360771 creator A5015324735 @default.
- W2313360771 creator A5018103775 @default.
- W2313360771 creator A5024057178 @default.
- W2313360771 creator A5031172003 @default.
- W2313360771 creator A5035791716 @default.
- W2313360771 creator A5053426908 @default.
- W2313360771 creator A5082694156 @default.
- W2313360771 date "1983-01-01" @default.
- W2313360771 modified "2023-09-26" @default.
- W2313360771 title "Regeneration characteristics of mitomycin C-dextran conjugate in relation to its activity." @default.
- W2313360771 cites W623019811 @default.
- W2313360771 doi "https://doi.org/10.1248/cpb.31.2055" @default.
- W2313360771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6196134" @default.
- W2313360771 hasPublicationYear "1983" @default.
- W2313360771 type Work @default.
- W2313360771 sameAs 2313360771 @default.
- W2313360771 citedByCount "47" @default.
- W2313360771 countsByYear W23133607712016 @default.
- W2313360771 countsByYear W23133607712019 @default.
- W2313360771 crossrefType "journal-article" @default.
- W2313360771 hasAuthorship W2313360771A5005177820 @default.
- W2313360771 hasAuthorship W2313360771A5015324735 @default.
- W2313360771 hasAuthorship W2313360771A5018103775 @default.
- W2313360771 hasAuthorship W2313360771A5024057178 @default.
- W2313360771 hasAuthorship W2313360771A5031172003 @default.
- W2313360771 hasAuthorship W2313360771A5035791716 @default.
- W2313360771 hasAuthorship W2313360771A5053426908 @default.
- W2313360771 hasAuthorship W2313360771A5082694156 @default.
- W2313360771 hasConcept C134306372 @default.
- W2313360771 hasConcept C141071460 @default.
- W2313360771 hasConcept C150903083 @default.
- W2313360771 hasConcept C185592680 @default.
- W2313360771 hasConcept C197336794 @default.
- W2313360771 hasConcept C202751555 @default.
- W2313360771 hasConcept C207001950 @default.
- W2313360771 hasConcept C2777339698 @default.
- W2313360771 hasConcept C2778439535 @default.
- W2313360771 hasConcept C2779338040 @default.
- W2313360771 hasConcept C33923547 @default.
- W2313360771 hasConcept C55493867 @default.
- W2313360771 hasConcept C71924100 @default.
- W2313360771 hasConcept C86803240 @default.
- W2313360771 hasConceptScore W2313360771C134306372 @default.
- W2313360771 hasConceptScore W2313360771C141071460 @default.
- W2313360771 hasConceptScore W2313360771C150903083 @default.
- W2313360771 hasConceptScore W2313360771C185592680 @default.
- W2313360771 hasConceptScore W2313360771C197336794 @default.
- W2313360771 hasConceptScore W2313360771C202751555 @default.
- W2313360771 hasConceptScore W2313360771C207001950 @default.
- W2313360771 hasConceptScore W2313360771C2777339698 @default.
- W2313360771 hasConceptScore W2313360771C2778439535 @default.
- W2313360771 hasConceptScore W2313360771C2779338040 @default.
- W2313360771 hasConceptScore W2313360771C33923547 @default.
- W2313360771 hasConceptScore W2313360771C55493867 @default.
- W2313360771 hasConceptScore W2313360771C71924100 @default.
- W2313360771 hasConceptScore W2313360771C86803240 @default.
- W2313360771 hasIssue "6" @default.
- W2313360771 hasLocation W23133607711 @default.
- W2313360771 hasLocation W23133607712 @default.
- W2313360771 hasOpenAccess W2313360771 @default.
- W2313360771 hasPrimaryLocation W23133607711 @default.
- W2313360771 hasRelatedWork W1989672218 @default.
- W2313360771 hasRelatedWork W2001199821 @default.
- W2313360771 hasRelatedWork W2156678100 @default.
- W2313360771 hasRelatedWork W2325170873 @default.
- W2313360771 hasRelatedWork W2424444077 @default.
- W2313360771 hasRelatedWork W2460428725 @default.
- W2313360771 hasRelatedWork W3025552567 @default.
- W2313360771 hasRelatedWork W4286914113 @default.
- W2313360771 hasRelatedWork W45310296 @default.
- W2313360771 hasRelatedWork W68772287 @default.
- W2313360771 hasVolume "31" @default.
- W2313360771 isParatext "false" @default.
- W2313360771 isRetracted "false" @default.
- W2313360771 magId "2313360771" @default.
- W2313360771 workType "article" @default.