Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313364580> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2313364580 endingPage "327" @default.
- W2313364580 startingPage "319" @default.
- W2313364580 abstract "It has been speculated that the reduction in vascular events by statins may not only be due to lowering of cholesterol, but also to the decrease in plasma C-reactive protein (CRP). In the present study we investigated the possibility that rosuvastatin directly affected CRP expression in stimulated human hepatocytes.Interleukin 6 (IL-6) stimulated human hepatoma cells (Hep3B) and primary human hepatocytes (PHH) were incubated with various concentrations of rosuvastatin (0.3 - 1 microM) for 24 hours. CRP expression was determined using ELISA and quantitative real-time RT-PCR. The activation of STAT3 and C/EBP was investigated utilizing transcription factor assays (TransAM).IL-6 increased CRP secretion by up to 5-fold in Hep3B and 6.6-fold in PHH. Rosuvastatin reduced CRP expression by 32% and 46% in Hep3B and PHH, respectively. IL-6 increased CRP mRNA up to 32-fold. At 1 microM, rosuvastatin reduced CRP mRNA by 73% compared to IL-6-stimulated cells. IL-6 activated the transcription factors STAT3 and C/EBP up to 2.6-fold and 2.2-fold, respectively. Rosuvastatin (1 microM) attenuated the activation of STAT3 and C/EBP by 48% and 54%, respectively.Our results show a direct inhibitory effect of rosuvastatin on IL-6-induced expression of CRP in liver cells. Statins may lower CRP by inhibiting its production in the liver rather than by exerting systemic anti-inflammatory effects. The effects of rosuvastatin in reducing the levels of CRP in plasma may have clinical utility in addition to its effects on atherogenic lipoproteins." @default.
- W2313364580 created "2016-06-24" @default.
- W2313364580 creator A5000046286 @default.
- W2313364580 creator A5026061775 @default.
- W2313364580 creator A5031774241 @default.
- W2313364580 creator A5038826650 @default.
- W2313364580 creator A5039161843 @default.
- W2313364580 creator A5040557338 @default.
- W2313364580 creator A5089027602 @default.
- W2313364580 date "2007-06-01" @default.
- W2313364580 modified "2023-10-16" @default.
- W2313364580 title "Rosuvastatin reduces interleukin-6-induced expression of C-reactive protein in human hepatocytes in a STAT3- and C/EBP- dependent fashion" @default.
- W2313364580 doi "https://doi.org/10.5414/cpp45319" @default.
- W2313364580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17595889" @default.
- W2313364580 hasPublicationYear "2007" @default.
- W2313364580 type Work @default.
- W2313364580 sameAs 2313364580 @default.
- W2313364580 citedByCount "38" @default.
- W2313364580 countsByYear W23133645802012 @default.
- W2313364580 countsByYear W23133645802013 @default.
- W2313364580 countsByYear W23133645802014 @default.
- W2313364580 countsByYear W23133645802015 @default.
- W2313364580 countsByYear W23133645802016 @default.
- W2313364580 countsByYear W23133645802019 @default.
- W2313364580 countsByYear W23133645802020 @default.
- W2313364580 countsByYear W23133645802021 @default.
- W2313364580 countsByYear W23133645802022 @default.
- W2313364580 countsByYear W23133645802023 @default.
- W2313364580 crossrefType "journal-article" @default.
- W2313364580 hasAuthorship W2313364580A5000046286 @default.
- W2313364580 hasAuthorship W2313364580A5026061775 @default.
- W2313364580 hasAuthorship W2313364580A5031774241 @default.
- W2313364580 hasAuthorship W2313364580A5038826650 @default.
- W2313364580 hasAuthorship W2313364580A5039161843 @default.
- W2313364580 hasAuthorship W2313364580A5040557338 @default.
- W2313364580 hasAuthorship W2313364580A5089027602 @default.
- W2313364580 hasConcept C11988809 @default.
- W2313364580 hasConcept C126322002 @default.
- W2313364580 hasConcept C134018914 @default.
- W2313364580 hasConcept C185592680 @default.
- W2313364580 hasConcept C2776914184 @default.
- W2313364580 hasConcept C2778690821 @default.
- W2313364580 hasConcept C2778923194 @default.
- W2313364580 hasConcept C2780499067 @default.
- W2313364580 hasConcept C2781195455 @default.
- W2313364580 hasConcept C55493867 @default.
- W2313364580 hasConcept C62478195 @default.
- W2313364580 hasConcept C71924100 @default.
- W2313364580 hasConcept C74172505 @default.
- W2313364580 hasConcept C86803240 @default.
- W2313364580 hasConceptScore W2313364580C11988809 @default.
- W2313364580 hasConceptScore W2313364580C126322002 @default.
- W2313364580 hasConceptScore W2313364580C134018914 @default.
- W2313364580 hasConceptScore W2313364580C185592680 @default.
- W2313364580 hasConceptScore W2313364580C2776914184 @default.
- W2313364580 hasConceptScore W2313364580C2778690821 @default.
- W2313364580 hasConceptScore W2313364580C2778923194 @default.
- W2313364580 hasConceptScore W2313364580C2780499067 @default.
- W2313364580 hasConceptScore W2313364580C2781195455 @default.
- W2313364580 hasConceptScore W2313364580C55493867 @default.
- W2313364580 hasConceptScore W2313364580C62478195 @default.
- W2313364580 hasConceptScore W2313364580C71924100 @default.
- W2313364580 hasConceptScore W2313364580C74172505 @default.
- W2313364580 hasConceptScore W2313364580C86803240 @default.
- W2313364580 hasIssue "06" @default.
- W2313364580 hasLocation W23133645801 @default.
- W2313364580 hasLocation W23133645802 @default.
- W2313364580 hasOpenAccess W2313364580 @default.
- W2313364580 hasPrimaryLocation W23133645801 @default.
- W2313364580 hasRelatedWork W1966296538 @default.
- W2313364580 hasRelatedWork W2009389088 @default.
- W2313364580 hasRelatedWork W2020367384 @default.
- W2313364580 hasRelatedWork W2097461389 @default.
- W2313364580 hasRelatedWork W2114259434 @default.
- W2313364580 hasRelatedWork W2159390875 @default.
- W2313364580 hasRelatedWork W2161296685 @default.
- W2313364580 hasRelatedWork W2313364580 @default.
- W2313364580 hasRelatedWork W2907032203 @default.
- W2313364580 hasRelatedWork W4255681344 @default.
- W2313364580 hasVolume "45" @default.
- W2313364580 isParatext "false" @default.
- W2313364580 isRetracted "false" @default.
- W2313364580 magId "2313364580" @default.
- W2313364580 workType "article" @default.