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- W2313367103 abstract "Na+-K+-2Cl- cotransporter 1 (NKCC1) and c-Jun N-terminal kinase (JNK) were immunohistochemically studied in guinea pig cochlea following the induction of endolymphatic hydrops by blocking the endolymphatic duct. Postoperative survivals were set to 1 day (n=3), 3 days (n=4), 1 week (n=3), 2 weeks (n=4), 1 month (n=4) and 3 months (n=4). The most striking finding was an increase in the immunoreactivity for NKCC1 at type 1 fibrocytes of the spiral ligament throughout the survival times. This suggests that the affected cells shrink as the result of surgical intervention and upregulate NKCC1 to restore the volume of the cells. The shrinkage of type 1 fibrocytes should reduce gap junctional connectivity among cells of the ligament, which could reduce K+ supply into the stria vascularis and disturb ionic homeostasis in the endolymph. On the other hand, JNK, which has been reported to activate NKCC1 by phosphorylation, showed a consistent decrease in immunoreactivity in the types 1 and 2 fibrocytes in hydropic ears, indicating that JNK does not play an important role in the activation of NKCC1 in the cochlea.The findings in the present study suggested that endolymphatic homeostasis depends on cell integrity within the spiral ligament and that NKCC1 in type 1 fibrocytes is crucial in maintaining cochlear fluid homeostasis." @default.
- W2313367103 created "2016-06-24" @default.
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- W2313367103 date "2001-01-01" @default.
- W2313367103 modified "2023-09-24" @default.
- W2313367103 title "Immunohistochemical Observation of Na+-K+-2Cl- Cotransporter and c-Jun N-terminal Kinase in Guinea Pig Cochlea with Experimentally Induced Endolymphatic Hydrops." @default.
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- W2313367103 doi "https://doi.org/10.5631/jibirin.94.555" @default.
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