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- W2313367740 abstract "Glypican-5 is one of the six members of the glypican family. It has been previously reported that glypican-5 stimulates the proliferation of rhabdomyosarcoma cells. In this study we show that this stimulatory activity of glypican-5 is due to its ability to promote Hedgehog signaling. We have previously shown that glypican-3, another member of the glypican family, inhibits Hedgehog signaling by competing with Patched for Hedgehog binding. Furthermore, we showed that glypican-3 binds to Hedgehog through its core protein but not to Patched. Here we demonstrate that glypican-5 can increase the binding of Sonic Hedgehog to Patched. We also show that glypican-5 can bind to both Hedgehog and Patched through its glycosaminoglycan chains. Interestingly, we found that the heparan sulfate chains of glypican-5 display a significantly higher degree of sulfation than those from glypican-3. In addition, we show that glypican-5 interacts with Hedgehog with a lower affinity than glypican-3. Based on these results, we propose that glypican-5 stimulates Hedgehog signaling by facilitating/stabilizing the interaction between Hedgehog and Patched. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3191." @default.
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- W2313367740 date "2010-04-15" @default.
- W2313367740 modified "2023-09-27" @default.
- W2313367740 title "Abstract 3191: Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating hedgehog signaling" @default.
- W2313367740 doi "https://doi.org/10.1158/1538-7445.am10-3191" @default.
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