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- W2313403910 abstract "Hypertrophic pachymeningitis (HP) is thought to have an autoimmune etiology but its precise cause and treatment remains to be elucidated. Here, we report the clinical details and therapeutic responses of 3 patients with HP and reviewed 66 previously reported cases in the literature. Among these patients, headache was the most frequent complaint. Cranial nerve involvement was also frequently observed, with the optic nerve being the most frequently impaired followed by the oculomotor, trochlear, and abducens nerves in frequency. Elevated C-reactive protein levels and erythrocyte sedimentation rates were found in approximately 97% of the patients. Steroids were the most commonly prescribed therapy, but no definite protocols for the standard dose and duration in HP have been proposed thus far. The average initial dose of prednisolone (PSL) was 42.7 mg/day, and the average maintenance dose was 12.4 mg/day in the chronic stage. Recurrence occurred in many patients when the dose of PSL was reduced to under 20 mg/day. Therefore, steroids should be tapered extremely slowly." @default.
- W2313403910 created "2016-06-24" @default.
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- W2313403910 date "2011-01-01" @default.
- W2313403910 modified "2023-10-02" @default.
- W2313403910 title "Hypertrophic pachymeningitis: Three adult cases and a review of the literature" @default.
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- W2313403910 doi "https://doi.org/10.5692/clinicalneurol.51.243" @default.
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