Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313426394> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2313426394 endingPage "18" @default.
- W2313426394 startingPage "1" @default.
- W2313426394 abstract "Efficacy of oral administration of BCG on the growth of various tumors in mice and guinea pigs was studied. The growth-inhibitory effect varied depending on the tumor systems and the experimental conditions. Weekly oral administrations with 5-mg doses of BCG to mice or 80-mg doses of BCG to guinea pigs were ineffective on syngeneic mouse melanoma B l6 or syngeneic guinea pig hepatocarcinoma line-10 but effective on syngeneic mouse carcinoma IMC and syngeneic guinea-pig fibrosarcoma H9A. Oral BCG seemed effective also on allogeneic mouse carcinoma Ehrlich, developed with a relatively small size of tumor cell inoculum, and on guinea-pig syngeneic liposarcoma H10. On Ehrlich tumors, oral BCG given once a week seemed to have better effects than did oral BCG given twice a week or subcutanously once or repeatedly; heat-killed BCG given orally showed no effect. However, it seems premature to draw a definite conclusion on the efficacy of oral BGG on Ehrlich and H10 tumors, because some of these tumors regressed spontaneously even in nontreated control animals.The host responses to oral BCG were studied with the following results. Weekly oral administrations with 80-mg doses of BCG to guinea pigs elicited positive skin reactions to 25 TU PPD in about 65 days after the first BCG, while a single sc injection of 8 mg of BCG did so within 10 days. Orally administered BCG organisms were recovered largely from Peyer's patches, a little from the mesenteric lymph nodes, and very little from the liver and the spleen. The BCG distributive pattern was in reverse order when BCG was given subcutaneously. Histologic examinations of Peyer's patches indicated enlargement of germinal centers, in which primitive reticular cells proliferated prominently and the macrophages with tingible bodies scattered frequently." @default.
- W2313426394 created "2016-06-24" @default.
- W2313426394 creator A5012270454 @default.
- W2313426394 creator A5014055693 @default.
- W2313426394 creator A5028359272 @default.
- W2313426394 creator A5044494440 @default.
- W2313426394 date "1979-01-01" @default.
- W2313426394 modified "2023-10-05" @default.
- W2313426394 title "IMMUNOTHERAPEUTIC TRIALS OF MURINE AND GUINEA-PIG SOLID TUMORS BY ORAL ADMINISTRATION OF BCG" @default.
- W2313426394 cites W1580086627 @default.
- W2313426394 cites W1968974831 @default.
- W2313426394 cites W1976454645 @default.
- W2313426394 cites W2029739305 @default.
- W2313426394 cites W2046804552 @default.
- W2313426394 cites W2055910073 @default.
- W2313426394 cites W2063140979 @default.
- W2313426394 cites W2115862599 @default.
- W2313426394 cites W2138626029 @default.
- W2313426394 cites W2409912500 @default.
- W2313426394 doi "https://doi.org/10.7883/yoken1952.32.1" @default.
- W2313426394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/470220" @default.
- W2313426394 hasPublicationYear "1979" @default.
- W2313426394 type Work @default.
- W2313426394 sameAs 2313426394 @default.
- W2313426394 citedByCount "7" @default.
- W2313426394 countsByYear W23134263942014 @default.
- W2313426394 crossrefType "journal-article" @default.
- W2313426394 hasAuthorship W2313426394A5012270454 @default.
- W2313426394 hasAuthorship W2313426394A5014055693 @default.
- W2313426394 hasAuthorship W2313426394A5028359272 @default.
- W2313426394 hasAuthorship W2313426394A5044494440 @default.
- W2313426394 hasBestOaLocation W23134263941 @default.
- W2313426394 hasConcept C126322002 @default.
- W2313426394 hasConcept C142724271 @default.
- W2313426394 hasConcept C203014093 @default.
- W2313426394 hasConcept C2776495794 @default.
- W2313426394 hasConcept C2777056448 @default.
- W2313426394 hasConcept C2777658100 @default.
- W2313426394 hasConcept C2778548629 @default.
- W2313426394 hasConcept C2778815084 @default.
- W2313426394 hasConcept C2779237934 @default.
- W2313426394 hasConcept C2779720271 @default.
- W2313426394 hasConcept C2780931953 @default.
- W2313426394 hasConcept C502942594 @default.
- W2313426394 hasConcept C71924100 @default.
- W2313426394 hasConcept C98274493 @default.
- W2313426394 hasConceptScore W2313426394C126322002 @default.
- W2313426394 hasConceptScore W2313426394C142724271 @default.
- W2313426394 hasConceptScore W2313426394C203014093 @default.
- W2313426394 hasConceptScore W2313426394C2776495794 @default.
- W2313426394 hasConceptScore W2313426394C2777056448 @default.
- W2313426394 hasConceptScore W2313426394C2777658100 @default.
- W2313426394 hasConceptScore W2313426394C2778548629 @default.
- W2313426394 hasConceptScore W2313426394C2778815084 @default.
- W2313426394 hasConceptScore W2313426394C2779237934 @default.
- W2313426394 hasConceptScore W2313426394C2779720271 @default.
- W2313426394 hasConceptScore W2313426394C2780931953 @default.
- W2313426394 hasConceptScore W2313426394C502942594 @default.
- W2313426394 hasConceptScore W2313426394C71924100 @default.
- W2313426394 hasConceptScore W2313426394C98274493 @default.
- W2313426394 hasIssue "1" @default.
- W2313426394 hasLocation W23134263941 @default.
- W2313426394 hasLocation W23134263942 @default.
- W2313426394 hasOpenAccess W2313426394 @default.
- W2313426394 hasPrimaryLocation W23134263941 @default.
- W2313426394 hasRelatedWork W1506420409 @default.
- W2313426394 hasRelatedWork W1538436890 @default.
- W2313426394 hasRelatedWork W158369705 @default.
- W2313426394 hasRelatedWork W1992244925 @default.
- W2313426394 hasRelatedWork W1999623084 @default.
- W2313426394 hasRelatedWork W2051141427 @default.
- W2313426394 hasRelatedWork W2053743302 @default.
- W2313426394 hasRelatedWork W2291698680 @default.
- W2313426394 hasRelatedWork W2313426394 @default.
- W2313426394 hasRelatedWork W2429115531 @default.
- W2313426394 hasVolume "32" @default.
- W2313426394 isParatext "false" @default.
- W2313426394 isRetracted "false" @default.
- W2313426394 magId "2313426394" @default.
- W2313426394 workType "article" @default.