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- W2313446085 abstract "In continuation of our program to find compounds with potent anti-human immunodeficiency virus type 1 (HIV-1) activities, seventeen 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives (1-17) were preliminarily evaluated as HIV-1 inhibitors in vitro. Among all the derivatives, especially compounds 10 and 17 showed the most potent anti-HIV-1 activities with EC50 values of 2.42 and 3.39 μg/mL, and TI values of 63.76 and 53.60, respectively. Keywords: 5,6-Dihydro-indolo[1,2-a]quinoxaline, Acquired immunodeficiency syndrome, Human immunodeficiency virus-1, Inhibitor, AIDS, quinoxaline, HIV-1, Syncytia Assay, MTT-based Cytotoxicity Assay, TCID50, calf serum, Anti-HIV-1 Activity Assay, HIV-1 IIIB, Reed and Muench method" @default.
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- W2313446085 date "2012-01-01" @default.
- W2313446085 modified "2023-09-26" @default.
- W2313446085 title "Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro" @default.
- W2313446085 doi "https://doi.org/10.2174/157018012798193026" @default.
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