Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313452457> ?p ?o ?g. }
- W2313452457 abstract "Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated axons following injury. At the neuroma that forms after damage, expression of Kv1.1 and 1.2 (normally localised to the juxtaparanode) was markedly decreased. In contrast Kv1.4 and 1.6, which were hardly detectable in the naïve state, showed increased expression within juxtaparanodes and paranodes following injury, both in rats and humans. Within the dorsal root (a site remote from injury) we noted a redistribution of Kv1-channels towards the paranode. Blockade of Kv1 channels with α-DTX after injury reinstated hyperexcitability of A-fibre axons and enhanced mechanosensitivity. Changes in the molecular composition and distribution of axonal Kv1 channels, therefore represents a protective mechanism to suppress the hyperexcitability of myelinated sensory axons that follows nerve injury." @default.
- W2313452457 created "2016-06-24" @default.
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- W2313452457 date "2016-04-01" @default.
- W2313452457 modified "2023-09-24" @default.
- W2313452457 title "Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury" @default.
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- W2313452457 cites W1623378741 @default.
- W2313452457 cites W1677506667 @default.
- W2313452457 cites W1764887409 @default.
- W2313452457 cites W1878253384 @default.
- W2313452457 cites W1911071268 @default.
- W2313452457 cites W1936127814 @default.
- W2313452457 cites W1965866432 @default.
- W2313452457 cites W1968532742 @default.
- W2313452457 cites W1971832928 @default.
- W2313452457 cites W1973073711 @default.
- W2313452457 cites W1975583239 @default.
- W2313452457 cites W1982110038 @default.
- W2313452457 cites W1983231052 @default.
- W2313452457 cites W1985133721 @default.
- W2313452457 cites W1987439527 @default.
- W2313452457 cites W1987711547 @default.
- W2313452457 cites W1990360679 @default.
- W2313452457 cites W1994193278 @default.
- W2313452457 cites W1994516788 @default.
- W2313452457 cites W1996951072 @default.
- W2313452457 cites W1998139699 @default.
- W2313452457 cites W1998741050 @default.
- W2313452457 cites W2002692790 @default.
- W2313452457 cites W2003542915 @default.
- W2313452457 cites W2004104083 @default.
- W2313452457 cites W2008128035 @default.
- W2313452457 cites W2014189974 @default.
- W2313452457 cites W2014642175 @default.
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- W2313452457 cites W2026278840 @default.
- W2313452457 cites W2027584400 @default.
- W2313452457 cites W2029376214 @default.
- W2313452457 cites W2032250203 @default.
- W2313452457 cites W2034351072 @default.
- W2313452457 cites W2039236777 @default.
- W2313452457 cites W2041388242 @default.
- W2313452457 cites W2045167317 @default.
- W2313452457 cites W2047439107 @default.
- W2313452457 cites W2049069390 @default.
- W2313452457 cites W2049217100 @default.
- W2313452457 cites W2057469839 @default.
- W2313452457 cites W2060363247 @default.
- W2313452457 cites W2060424507 @default.
- W2313452457 cites W2071595010 @default.
- W2313452457 cites W2081167569 @default.
- W2313452457 cites W2081533056 @default.
- W2313452457 cites W2085241987 @default.
- W2313452457 cites W2088734315 @default.
- W2313452457 cites W2104818454 @default.
- W2313452457 cites W2122971055 @default.
- W2313452457 cites W2139180043 @default.
- W2313452457 cites W2143699287 @default.
- W2313452457 cites W2151301539 @default.
- W2313452457 cites W2152963050 @default.
- W2313452457 cites W2154646032 @default.
- W2313452457 cites W2155763675 @default.
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- W2313452457 cites W2161225981 @default.
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- W2313452457 cites W2416337138 @default.
- W2313452457 cites W4229587511 @default.
- W2313452457 cites W4296816736 @default.
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- W2313452457 doi "https://doi.org/10.7554/elife.12661" @default.
- W2313452457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4841771" @default.
- W2313452457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27033551" @default.
- W2313452457 hasPublicationYear "2016" @default.
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