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- W2313461935 abstract "Corticosteroid-induced isoenzyme of alkaline phosphatase (AP) can easily be demonstrated in canine plasma as a routine procedure because of its greater heat stability at 65 degrees C in comparison with that of other AP-isoenzymes. In this study the accuracy of this test for the diagnosis of hypercorticism was investigated. The AP-65 degrees C test had its highest efficiency when applied to plasma AP levels exceeding 150 units/litre. In a group of 146 dogs, clinically suspected of having hyperadrenocorticism, the test had a sensitivity of 0.92 and a positive predictive value for a positive test result of 0.89. Its lack of specificity (0.44) makes it unsuitable as a diagnostic test. The main application of AP-65 degrees C is in detecting hypercorticism in dogs by routine laboratory measurements, as was demonstrated in 711 dogs, in which a positive predictive value for the presence of hypercorticism of 0.89 was found." @default.
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- W2313461935 date "1989-07-01" @default.
- W2313461935 modified "2023-10-17" @default.
- W2313461935 title "Corticosteroid-induced alkaline phosphatase isoenzyme in the diagnosis of canine hypercorticism" @default.
- W2313461935 doi "https://doi.org/10.1136/vr.125.1.12" @default.
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