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- W2313474089 abstract "SummaryAdministration of acid extract of cattle anterior pituitary, when continued over long periods of time, leads to the following changes at the chondro-osseous junction of the ribs of the growing guinea pig: (1) The preexisting resting and columnar cartilage cells undergo hyperplastic and hypertrophie changes which are associated with certain retrogressive processes in the cells. (2) In the cells of the perichondrium and periosteum a pronounced hyperplasia takes place followed by an accelerated conversion of these cells into cartilaginous tissue with subsequent calcification. (3) The bone marrow becomes transformed into fibrous connective tissue in which cartilaginous islands develop in places adjoining the hyperplastic cartilage. Through the cooperation of both these growth processes an abundance of cartilage may develop.We find various transitions between ordinary hypertrophy and hyperplasia of the preexisting cartilage cells to the formation of a rosary-like newgrowth. In advanced cases, at a time ..." @default.
- W2313474089 created "2016-06-24" @default.
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- W2313474089 date "1937-06-01" @default.
- W2313474089 modified "2023-09-27" @default.
- W2313474089 title "Changes in Ribs of Guinea Pigs Following Administration of Cattle Anterior Pituitary Extract. (Acromegalic Rosary)" @default.
- W2313474089 doi "https://doi.org/10.3181/00379727-36-9335" @default.
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