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- W2313477055 abstract "Chlorpheniramine maleate (CPM) in tablet (CPM-T), powder (CPM-P) and injection (CPM-I) forms according to The Japanese Pharmacopoeia Thirteenth Edition (JP-XIII) was determined by the two-phase photometric ion-pair titration (TPPIT) method using Methyl Orange (MO) as the titrant. Ten ml of a buffer solution (pH 5) and 40 ml of dichloromethane (DCM) were added to a sample containing about 0.5 mg CPM and titrate in a 1 × 10-3 M MO standard solution; the solution was then stirred for 2 minutes. After the solution was separated into two layers, the absorbance of the DCM layer was measured at 425 nm. By repeating this operation, a titration curve was prepared and the titration end point was obtained. The amount of CPM was calculated, and compared with that determined by the JP-XIII method. No significant difference was found in the accuracy between the two methods. Therefore, the TPPIT method is a useful method for the determination of CPM." @default.
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- W2313477055 date "1997-01-01" @default.
- W2313477055 modified "2023-09-26" @default.
- W2313477055 title "Two-phase photometric ion-pair titration of chlorpheniramine maleate in tablet, powder and injection form using methyl orange as the titrant." @default.
- W2313477055 doi "https://doi.org/10.2116/bunsekikagaku.46.117" @default.
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