Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313493430> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2313493430 endingPage "444" @default.
- W2313493430 startingPage "437" @default.
- W2313493430 abstract "Ventricular fibrosis plays a pivotal role in the development of diastolic heart failure and is a therapeutic target; however, the effects of pharmacological interventions on the extracellular matrix (ECM) regulatory system in diastolic heart failure remain to be clarified.Dahl salt-sensitive rats fed on a diet containing 8% NaCl from age 7 weeks--a hypertensive diastolic heart failure model--were divided into untreated rats, rats treated with angiotensin II type 1 (AT1) receptor antagonist and those treated with endothelin type A (ETA) receptor antagonist.Ventricular fibrosis progressed in the untreated rats, with increases in mRNA levels of type I collagen, matrix metalloproteinase-2, -9 and -13, and tissue inhibitor of metalloproteinase-1 and -2. Both antagonists attenuated ventricular fibrosis to the same degree. AT1 receptor blockade decreased the type I collagen mRNA level more than ETA receptor blockade. ETA receptor blockade did not decrease the matrix metalloproteinase-2 mRNA level that was decreased by AT1 receptor blockade, and decreased the tissue inhibitor of metalloproteinase-2 mRNA level that was not affected by AT1 receptor blockade. These led to a higher ratio of matrix metalloproteinase-2 to tissue inhibitor of metalloproteinase-2 mRNA levels and a greater 72-kDa gelatinase activity in the rats treated with ETA receptor antagonist than in those treated with AT1 receptor antagonist, and may well cancel out the lesser decline in collagen synthesis, resulting in the equivalent attenuation of ventricular fibrosis.AT1 receptor and ETA receptor antagonists provide their beneficial effects on the ECM through different modulation of its regulatory system." @default.
- W2313493430 created "2016-06-24" @default.
- W2313493430 creator A5018573172 @default.
- W2313493430 creator A5025153902 @default.
- W2313493430 creator A5033804823 @default.
- W2313493430 creator A5045956357 @default.
- W2313493430 creator A5049340312 @default.
- W2313493430 creator A5064738789 @default.
- W2313493430 creator A5083909742 @default.
- W2313493430 creator A5084625643 @default.
- W2313493430 date "2003-02-01" @default.
- W2313493430 modified "2023-09-27" @default.
- W2313493430 title "Angiotensin II type 1 and endothelin type A receptor antagonists modulate the extracellular matrix regulatory system differently in diastolic heart failure" @default.
- W2313493430 cites W1547783254 @default.
- W2313493430 cites W1969869274 @default.
- W2313493430 cites W1984110231 @default.
- W2313493430 cites W2007946529 @default.
- W2313493430 cites W2014629399 @default.
- W2313493430 cites W2014683929 @default.
- W2313493430 cites W2044261018 @default.
- W2313493430 cites W2067862320 @default.
- W2313493430 cites W2076561457 @default.
- W2313493430 cites W2082672791 @default.
- W2313493430 cites W2083834362 @default.
- W2313493430 cites W2087324240 @default.
- W2313493430 cites W2100629191 @default.
- W2313493430 cites W2105161080 @default.
- W2313493430 cites W2134743993 @default.
- W2313493430 cites W2143756095 @default.
- W2313493430 cites W2148795098 @default.
- W2313493430 cites W2159716161 @default.
- W2313493430 cites W332592564 @default.
- W2313493430 doi "https://doi.org/10.1097/00004872-200302000-00037" @default.
- W2313493430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12569276" @default.
- W2313493430 hasPublicationYear "2003" @default.
- W2313493430 type Work @default.
- W2313493430 sameAs 2313493430 @default.
- W2313493430 citedByCount "18" @default.
- W2313493430 countsByYear W23134934302021 @default.
- W2313493430 crossrefType "journal-article" @default.
- W2313493430 hasAuthorship W2313493430A5018573172 @default.
- W2313493430 hasAuthorship W2313493430A5025153902 @default.
- W2313493430 hasAuthorship W2313493430A5033804823 @default.
- W2313493430 hasAuthorship W2313493430A5045956357 @default.
- W2313493430 hasAuthorship W2313493430A5049340312 @default.
- W2313493430 hasAuthorship W2313493430A5064738789 @default.
- W2313493430 hasAuthorship W2313493430A5083909742 @default.
- W2313493430 hasAuthorship W2313493430A5084625643 @default.
- W2313493430 hasConcept C123915805 @default.
- W2313493430 hasConcept C126322002 @default.
- W2313493430 hasConcept C134018914 @default.
- W2313493430 hasConcept C144980905 @default.
- W2313493430 hasConcept C170493617 @default.
- W2313493430 hasConcept C2776885963 @default.
- W2313493430 hasConcept C2778122271 @default.
- W2313493430 hasConcept C2778198053 @default.
- W2313493430 hasConcept C2780559512 @default.
- W2313493430 hasConcept C2908929049 @default.
- W2313493430 hasConcept C3018763269 @default.
- W2313493430 hasConcept C71924100 @default.
- W2313493430 hasConceptScore W2313493430C123915805 @default.
- W2313493430 hasConceptScore W2313493430C126322002 @default.
- W2313493430 hasConceptScore W2313493430C134018914 @default.
- W2313493430 hasConceptScore W2313493430C144980905 @default.
- W2313493430 hasConceptScore W2313493430C170493617 @default.
- W2313493430 hasConceptScore W2313493430C2776885963 @default.
- W2313493430 hasConceptScore W2313493430C2778122271 @default.
- W2313493430 hasConceptScore W2313493430C2778198053 @default.
- W2313493430 hasConceptScore W2313493430C2780559512 @default.
- W2313493430 hasConceptScore W2313493430C2908929049 @default.
- W2313493430 hasConceptScore W2313493430C3018763269 @default.
- W2313493430 hasConceptScore W2313493430C71924100 @default.
- W2313493430 hasIssue "2" @default.
- W2313493430 hasLocation W23134934301 @default.
- W2313493430 hasLocation W23134934302 @default.
- W2313493430 hasOpenAccess W2313493430 @default.
- W2313493430 hasPrimaryLocation W23134934301 @default.
- W2313493430 hasRelatedWork W1966128948 @default.
- W2313493430 hasRelatedWork W1971613811 @default.
- W2313493430 hasRelatedWork W1974641745 @default.
- W2313493430 hasRelatedWork W2077960701 @default.
- W2313493430 hasRelatedWork W2137237120 @default.
- W2313493430 hasRelatedWork W2149410839 @default.
- W2313493430 hasRelatedWork W2162471541 @default.
- W2313493430 hasRelatedWork W2313493430 @default.
- W2313493430 hasRelatedWork W2393521223 @default.
- W2313493430 hasRelatedWork W2907948471 @default.
- W2313493430 hasVolume "21" @default.
- W2313493430 isParatext "false" @default.
- W2313493430 isRetracted "false" @default.
- W2313493430 magId "2313493430" @default.
- W2313493430 workType "article" @default.