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• W2313508247 abstract "Five new tetrahydrofuran lignans (1-5), accompanied by four known compounds, were isolated from the ethyl acetate extract of Peperomia dindygulensis. Structures were elucidated mainly using 1D NMR, 2D NMR, and mass spectroscopic studies. The relative configurations of 1-5 were determined by NOE correlations. Several of the compounds showed weak growth inhibitory activity against three cell lines (WI-38, VA-13, and HepG2). Compound 5 exhibited stronger MDR (multidrug resistance) reversal activity than verapamil at 2.5 microg/mL in a cellular calcein accumulation assay. Compounds 4 and 5 showed weak inhibitory activity against induction of the intercellular adhesion molecule-1 (ICAM-1) in anti-inflammatory activity experiments." @default.
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• W2313508247 date "2005-10-14" @default.
• W2313508247 modified "2023-09-23" @default.
• W2313508247 title "Bioactive Tetrahydrofuran Lignans from <i>Peperomia </i><i>d</i><i>indygulensis</i>" @default.
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• W2313508247 doi "https://doi.org/10.1021/np050283e" @default.
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