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• W2313568356 abstract "<i>Astragalus englerianus</i> is a close relative of the traditional Chinese medicine plant Radix Astragali (Huang-qi) and is mainly distributed in Yunnan. It has been traditionally used as a substitute of “Huang-qi” for reducing fatigue and enhancing immunity by local folks. A phytochemical study of the methanol extract of the roots led to the isolation of three new flavonoids including one aurone (<b>1</b>) and two chalcones (<b>2</b> and <b>3</b>), as well as two known flavonoids (<b>4</b> and <b>5</b>). Their structures were elucidated based on the analyses of extensive spectroscopic data and comparison of their physicochemical properties. This is the first report on the occurrence of <i>β</i>-hydroxydihydrochalcone, 2′,5′-dioxygenchalcones, and 2′,5′-dioxygenaurone in the genus <i>Astragalus</i>. All the isolated compounds were tested <i>in vitro</i> for their schistosomicidal and antioxidant activities. Compounds <b>2</b> and <b>4</b> showed schistosomicidal activities with worm mortality rates of 100 % within 12 h in a drug-containing (0.70 and 0.77 mM, respectively) RPMI 1640 medium. Compounds <b>1</b> and <b>2</b> exhibited antioxidant activities in 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl free radical scavenging assays, with IC₅₀ values of 35.9 ± 1.1 and 12.2 ± 1.1 µM, respectively." @default.
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• W2313568356 date "2014-11-05" @default.
• W2313568356 modified "2023-09-22" @default.
• W2313568356 title "Schistosomicidal and Antioxidant Flavonoids from Astragalus englerianus" @default.
• W2313568356 doi "https://doi.org/10.1055/s-0034-1383219" @default.
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